Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACKR3 | P25106 | 2/20 | 0.51 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.51 |
| ▸ | CHRM4 | P08173 | 4/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | BTK | Q06187 | 1/20 | 0.44 |
| ▸ | PPARA | Q07869 | 5/20 | 0.44 |
| ▸ | PPARD | Q03181 | 3/20 | 0.44 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.43 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.43 |
| ▸ | POLR1A | O95602 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3405647 | 0.93 | ACKR3 (0.50) | ACKR3CHRM3CHRM4NPC1HPGD | |
| SCHEMBL3400075 | 0.92 | ACKR3 (0.54) | ACKR3CHRM3CHRM4NPC1HPGD | |
| SCHEMBL3405220 | 0.90 | ACKR3 (0.52) | ACKR3CHRM4NPC1HPGDBTK | |
| SCHEMBL3403919 | 0.90 | ACKR3 (0.51) | ACKR3CHRM4NPC1HPGDBTK | |
| SCHEMBL3398440 | 0.89 | ACKR3 (0.51) | ACKR3CHRM3CHRM4NPC1HPGD | |
| SCHEMBL3402424 | 0.88 | ACKR3 (0.50) | ACKR3CHRM4NPC1HPGDPPARA | |
| SCHEMBL3402412 | 0.86 | ACKR3 (0.53) | ACKR3CHRM4NPC1HPGDPPARA | |
| SCHEMBL3405362 | 0.86 | ACKR3 (0.55) | ACKR3CHRM4NPC1HPGDBTK | |
| SCHEMBL3429158 | 0.86 | GLA (0.51) | CHRM4NPC1HPGDMAPTTP53 | |
| SCHEMBL3402209 | 0.85 | ACKR3 (0.52) | ACKR3CHRM4NPC1HPGDPPARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| WO-2006089076-A9 | THIAZOLE AMIDES, IMIDAZOLE AMIDES AND RELATED ANALOGUES | NEUROGEN CORP (US) | 2007-04-26 | — | — | WO | disclosed |