Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACKR3 | P25106 | 2/20 | 0.55 |
| ▸ | CHRM4 | P08173 | 4/20 | 0.54 |
| ▸ | POLR1A | O95602 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | BTK | Q06187 | 1/20 | 0.45 |
| ▸ | PPARA | Q07869 | 4/20 | 0.44 |
| ▸ | PPARD | Q03181 | 3/20 | 0.44 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.43 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.43 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.43 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.43 |
| ▸ | CHRNB3 | Q05901 | 1/20 | 0.43 |
| ▸ | BRAF | P15056 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | PPARG | P37231 | 1/20 | 0.43 |
| ▸ | ACP1 | P24666 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3403412 | 0.91 | CHRM4 (0.49) | ACKR3CHRM4BTKPPARAPPARD | |
| SCHEMBL3405442 | 0.89 | ACKR3 (0.59) | ACKR3CHRM4NPC1HPGDBTK | |
| SCHEMBL3405145 | 0.89 | CHRM4 (0.52) | ACKR3CHRM4POLR1ANPC1HPGD | |
| SCHEMBL3400075 | 0.88 | ACKR3 (0.54) | ACKR3CHRM4NPC1HPGDBTK | |
| SCHEMBL3402461 | 0.87 | CHRM4 (0.55) | ACKR3CHRM4PPARAPPARDSMN1; SMN2 | |
| SCHEMBL13309884 | 0.87 | CHRM4 (0.51) | ACKR3CHRM4PPARAPPARDPPARG | |
| SCHEMBL3401785 | 0.87 | ACKR3 (0.54) | ACKR3CHRM4NPC1HPGDPPARA | |
| SCHEMBL3405722 | 0.86 | CHRM4 (0.50) | ACKR3CHRM4NPC1HPGDBTK | |
| SCHEMBL3403460 | 0.86 | CHRM4 (0.54) | ACKR3CHRM4NPC1HPGDPPARA | |
| SCHEMBL3403598 | 0.86 | ACKR3 (0.53) | ACKR3CHRM4PPARAPPARDPPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| WO-2006089076-A9 | THIAZOLE AMIDES, IMIDAZOLE AMIDES AND RELATED ANALOGUES | NEUROGEN CORP (US) | 2007-04-26 | — | — | WO | disclosed |