Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACKR3 | P25106 | 2/20 | 0.52 |
| ▸ | CHRM4 | P08173 | 4/20 | 0.49 |
| ▸ | PPARA | Q07869 | 5/20 | 0.44 |
| ▸ | PPARD | Q03181 | 4/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | PPARG | P37231 | 2/20 | 0.41 |
| ▸ | LCK | P06239 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | HTR1A | P08908 | 2/20 | 0.41 |
| ▸ | POLR1A | O95602 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3400075 | 0.88 | ACKR3 (0.54) | ACKR3CHRM4PPARAPPARDNPC1 | |
| SCHEMBL3402412 | 0.87 | ACKR3 (0.53) | ACKR3CHRM4PPARAPPARDNPC1 | |
| SCHEMBL3399976 | 0.86 | ACKR3 (0.52) | ACKR3CHRM4PPARAPPARDNPC1 | |
| SCHEMBL3403919 | 0.85 | ACKR3 (0.51) | ACKR3CHRM4PPARAPPARDNPC1 | |
| SCHEMBL13310232 | 0.85 | CHRM4 (0.57) | ACKR3CHRM4PPARAPPARDNPC1 | |
| SCHEMBL3402628 | 0.85 | ACKR3 (0.51) | ACKR3CHRM4PPARAPPARDNPC1 | |
| SCHEMBL3405362 | 0.85 | ACKR3 (0.55) | ACKR3CHRM4PPARAPPARDNPC1 | |
| SCHEMBL3398440 | 0.84 | ACKR3 (0.51) | ACKR3CHRM4PPARAPPARDNPC1 | |
| SCHEMBL3405145 | 0.84 | CHRM4 (0.52) | ACKR3CHRM4PPARAPPARDNPC1 | |
| SCHEMBL3402472 | 0.84 | HPGD (0.47) | CHRM4PPARAPPARDNPC1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |