Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 11/20 | 0.42 |
| ▸ | SOAT2 | O75908 | 1/20 | 0.41 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.41 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | PPARG | P37231 | 1/20 | 0.36 |
| ▸ | PPARD | Q03181 | 1/20 | 0.36 |
| ▸ | PPARA | Q07869 | 1/20 | 0.36 |
| ▸ | BACE1 | P56817 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL719083 | 0.83 | GCK (0.42) | DGAT1SOAT2SOAT1DGAT2KDM4E | |
| SCHEMBL719057 | 0.78 | DGAT1 (0.42) | DGAT1SOAT2SOAT1DGAT2KDM4E | |
| SCHEMBL721152 | 0.71 | DGAT1 (0.38) | DGAT1SOAT2SOAT1DGAT2KDM4E | |
| SCHEMBL457981 | 0.70 | P4HTM (0.56) | KDM4ESMN1; SMN2L3MBTL1ALDH1A1 | |
| SCHEMBL26676605 | 0.68 | SLC26A4 (0.62) | KDM4ESMN1; SMN2L3MBTL1ALDH1A1 | |
| SCHEMBL718396 | 0.68 | DGAT1 (0.37) | DGAT1SOAT2SOAT1DGAT2KDM4E | |
| SCHEMBL718963 | 0.66 | KDM4E (0.53) | KDM4ENPC1RAB9ASMN1; SMN2L3MBTL1 | |
| SCHEMBL720443 | 0.64 | GCK (0.46) | DGAT1SOAT2SOAT1DGAT2KDM4E | |
| SCHEMBL26676574 | 0.64 | SLC26A4 (0.60) | KDM4ESMN1; SMN2L3MBTL1ALDH1A1 | |
| SCHEMBL26676526 | 0.64 | SLC26A4 (0.60) | KDM4ESMN1; SMN2L3MBTL1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2251326-A1 | HETEROCYCLIC COMPOUND | Takeda Pharmaceutical Company Limited (JP) | 2010-11-17 | — | — | EP | disclosed |