Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 13/20 | 0.56 |
| ▸ | JAK2 | O60674 | 9/20 | 0.56 |
| ▸ | ZAP70 | P43403 | 9/20 | 0.56 |
| ▸ | LYN | P07948 | 8/20 | 0.56 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.39 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.39 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.38 |
| ▸ | RET | P07949 | 1/20 | 0.38 |
| ▸ | FLT3 | P36888 | 1/20 | 0.38 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | MELK | Q14680 | 2/20 | 0.32 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.32 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.32 |
| ▸ | CCNK | O75909 | 1/20 | 0.32 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.32 |
| ▸ | CDK2 | P24941 | 1/20 | 0.32 |
| ▸ | CDK9 | P50750 | 1/20 | 0.32 |
| ▸ | CDK12 | Q9NYV4 | 1/20 | 0.32 |
| ▸ | MAPK3 | P27361 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1056433 | 0.81 | SYK (0.60) | SYKJAK2ZAP70LYNKCNH2 | |
| SCHEMBL3403103 | 0.80 | SYK (0.34) | SYKJAK2ZAP70LYNKCNH2 | |
| SCHEMBL12932027 | 0.79 | SYK (0.58) | SYKJAK2ZAP70LYNKCNH2 | |
| SCHEMBL1053859 | 0.77 | SYK (0.71) | SYKJAK2ZAP70LYNKCNH2 | |
| SCHEMBL13745953 | 0.76 | SYK (0.67) | SYKJAK2ZAP70LYNKCNH2 | |
| SCHEMBL1053640 | 0.76 | SYK (0.67) | SYKJAK2ZAP70LYNKCNH2 | |
| SCHEMBL1060374 | 0.75 | SYK (0.63) | SYKJAK2ZAP70LYNKCNH2 | |
| SCHEMBL1051535 | 0.74 | SYK (0.65) | SYKJAK2ZAP70LYNKCNH2 | |
| SCHEMBL3403293 | 0.74 | SYK (0.64) | SYKJAK2ZAP70LYNKCNH2 | |
| SCHEMBL1057690 | 0.73 | SYK (0.65) | SYKJAK2ZAP70LYNKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2250169-A1 | PYRIDO [4, 3-D]PYRIMIDINONE DERIVATIVES AS KINASE INHIBITORS | IRM LLC (BM) | 2010-11-17 | — | — | EP | disclosed |
| WO-2009099801-A1 | PYRIDO [4, 3-D] PYRIMIDINONE DERIVATIVES AS KINASE INHIBITORS | IRM LLC (BM) | 2009-08-13 | — | — | WO | disclosed |