Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 10/20 | 0.34 |
| ▸ | JAK2 | O60674 | 8/20 | 0.34 |
| ▸ | LYN | P07948 | 8/20 | 0.34 |
| ▸ | ZAP70 | P43403 | 8/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | PARP1 | P09874 | 1/20 | 0.32 |
| ▸ | RET | P07949 | 1/20 | 0.31 |
| ▸ | FLT3 | P36888 | 1/20 | 0.31 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1053167 | 0.75 | SYK (0.47) | SYKJAK2LYNZAP70KCNH2 | |
| SCHEMBL15760952 | 0.70 | PARP1 (0.43) | SYKJAK2LYNZAP70KCNH2 | |
| SCHEMBL1059335 | 0.70 | PARP1 (0.44) | SYKJAK2LYNZAP70KCNH2 | |
| SCHEMBL29891348 | 0.68 | TYK2 (0.42) | SYKJAK2LYNZAP70 | |
| SCHEMBL1058535 | 0.68 | PARP1 (0.49) | JAK2ZAP70PARP1 | |
| SCHEMBL1057202 | 0.67 | SYK (0.45) | SYKJAK2 | |
| SCHEMBL1056394 | 0.66 | CDK1 (0.49) | SYKJAK2 | |
| SCHEMBL1058856 | 0.66 | LRRK2 (0.52) | SYKZAP70PARP1 | |
| SCHEMBL1057076 | 0.66 | JAK1 (0.41) | SYKJAK2PARP1 | |
| SCHEMBL1047700 | 0.64 | SYK (0.57) | SYKJAK2ZAP70 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2250169-A1 | PYRIDO [4, 3-D]PYRIMIDINONE DERIVATIVES AS KINASE INHIBITORS | IRM LLC (BM) | 2010-11-17 | — | — | EP | claimed |
| WO-2009099801-A1 | PYRIDO [4, 3-D] PYRIMIDINONE DERIVATIVES AS KINASE INHIBITORS | IRM LLC (BM) | 2009-08-13 | — | — | WO | claimed |
| EP-2250169-A1 | PYRIDO [4, 3-D]PYRIMIDINONE DERIVATIVES AS KINASE INHIBITORS | IRM LLC (BM) | 2010-11-17 | — | — | EP | disclosed |
| WO-2009099801-A1 | PYRIDO [4, 3-D] PYRIMIDINONE DERIVATIVES AS KINASE INHIBITORS | IRM LLC (BM) | 2009-08-13 | — | — | WO | disclosed |