Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 3/20 | 0.51 |
| ▸ | MEN1 | O00255 | 5/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 6/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 6/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 6/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 6/20 | 0.43 |
| ▸ | USP2 | O75604 | 5/20 | 0.43 |
| ▸ | TSHR | P16473 | 3/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.43 |
| ▸ | ABL1 | P00519 | 1/20 | 0.43 |
| ▸ | SRC | P12931 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | MAP2K7 | O14733 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3403276 | 0.89 | CYP1A2 (0.47) | HIF1AMEN1KMT2ALMNACYP1A2 | |
| SCHEMBL3267206 | 0.87 | HIF1A (0.57) | HIF1AMEN1KMT2ALMNACYP1A2 | |
| SCHEMBL3267065 | 0.83 | MEN1 (0.53) | HIF1AMEN1KMT2ALMNACYP1A2 | |
| SCHEMBL3408313 | 0.82 | MAPT (0.55) | HIF1AMEN1KMT2ATSHRMAPT | |
| SCHEMBL3407930 | 0.82 | ALDH1A1 (0.49) | HIF1AABL1MAPTMAPK1ALDH1A1 | |
| SCHEMBL3268659 | 0.82 | NPC1 (0.57) | MEN1KMT2AMAPTALDH1A1TP53 | |
| SCHEMBL3270944 | 0.82 | MAPT (0.49) | HIF1AMEN1KMT2ALMNACYP1A2 | |
| SCHEMBL3406201 | 0.80 | CHEK1 (0.49) | HIF1AABL1MAPTMAPK1 | |
| SCHEMBL3402633 | 0.79 | EPHX2 (0.44) | HIF1AABL1MAPTMAPK1 | |
| SCHEMBL3268616 | 0.78 | PDGFRB (0.53) | HIF1AMEN1KMT2ALMNACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2254666-A1 | 2-AMINOQUINOLINES AS 5-HT5A RECEPTOR ANTAGONISTS | F. Hoffmann-La Roche AG (CH) | 2010-12-01 | — | — | EP | claimed |
| WO-2009112395-A1 | 2-AMINOQUINOLINES AS 5-HT5A RECEPTOR ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2009-09-17 | — | — | WO | claimed |
| US-8350028-B2 | 2-aminoquinolines | HOFMANN-LA ROCHE INC. (US) | 2013-01-08 | — | — | US | disclosed |
| EP-2254666-A1 | 2-AMINOQUINOLINES AS 5-HT5A RECEPTOR ANTAGONISTS | F. Hoffmann-La Roche AG (CH) | 2010-12-01 | — | — | EP | disclosed |
| WO-2009112395-A1 | 2-AMINOQUINOLINES AS 5-HT5A RECEPTOR ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2009-09-17 | — | — | WO | disclosed |
| US-20090233927-A1 | 2-AMINOQUINOLINES | F. HOFFMANN-LA ROCHE AG (CH) | 2009-09-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090233927-A1 | 2-AMINOQUINOLINES | HTR5A, HTR2C, HTR2B | HIF1A 1296/4885MEN1 3729/4885KMT2A 1049/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.