Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 16/20 | 0.47 |
| ▸ | JAK2 | O60674 | 9/20 | 0.47 |
| ▸ | LYN | P07948 | 9/20 | 0.47 |
| ▸ | ZAP70 | P43403 | 9/20 | 0.47 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.47 |
| ▸ | TYRO3 | Q06418 | 2/20 | 0.47 |
| ▸ | RET | P07949 | 2/20 | 0.47 |
| ▸ | FLT3 | P36888 | 2/20 | 0.47 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.47 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.47 |
| ▸ | CDC7 | O00311 | 1/20 | 0.47 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.47 |
| ▸ | PLK4 | O00444 | 1/20 | 0.47 |
| ▸ | STK25 | O00506 | 1/20 | 0.47 |
| ▸ | CIT | O14578 | 1/20 | 0.47 |
| ▸ | RIOK3 | O14730 | 1/20 | 0.47 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.47 |
| ▸ | IKBKB | O14920 | 1/20 | 0.47 |
| ▸ | AURKA | O14965 | 1/20 | 0.47 |
| ▸ | GAK | O14976 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1056433 | 0.79 | SYK (0.60) | SYKJAK2LYNZAP70ADORA3 | |
| SCHEMBL1053457 | 0.79 | SYK (0.39) | SYKJAK2LYNZAP70ADORA3 | |
| SCHEMBL3403103 | 0.75 | SYK (0.34) | SYKJAK2LYNZAP70RET | |
| SCHEMBL1083288 | 0.74 | SYK (0.62) | SYKJAK2LYNZAP70ADORA3 | |
| SCHEMBL22068257 | 0.73 | SYK (0.69) | SYKJAK2LYNZAP70ADORA3 | |
| SCHEMBL15760952 | 0.72 | PARP1 (0.43) | SYKJAK2LYNZAP70CHEK1 | |
| SCHEMBL29671171 | 0.72 | SYK (0.52) | SYKJAK2LYNZAP70ADORA3 | |
| SCHEMBL16606964 | 0.72 | SYK (0.52) | SYKJAK2LYNZAP70ADORA3 | |
| SCHEMBL1059335 | 0.72 | PARP1 (0.44) | SYKJAK2LYNZAP70RET | |
| SCHEMBL14235384 | 0.71 | SYK (0.49) | SYKJAK2LYNZAP70ADORA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8354526-B2 | Pyrido [4, 3-D] pyrimidinone derivatives as kinase inhibitors | IRM LLC (BM) | 2013-01-15 | — | — | US | claimed |
| US-20110003790-A1 | PYRIDO [4, 3-D] PYRIMIDINONE DERIVATIVES AS KINASE INHIBITORS | IRM LLC (BM) | 2011-01-06 | — | — | US | claimed |
| US-8354526-B2 | Pyrido [4, 3-D] pyrimidinone derivatives as kinase inhibitors | IRM LLC (BM) | 2013-01-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110003790-A1 | PYRIDO [4, 3-D] PYRIMIDINONE DERIVATIVES AS KINASE INHIBITORS | ZAP70, FLT3, LCK | SYK 18/4885JAK2 58/4885LYN 77/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.