Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 2/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | CHRM3 | P20309 | 9/20 | 0.43 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.42 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.42 |
| ▸ | FAAH | O00519 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3402093 | 0.89 | ALDH1A1 (0.48) | ALOX15CYP2D6CYP2C9TSHRCYP2C19 | |
| SCHEMBL1362326 | 0.85 | IDO1 (0.45) | ALDH1A1KDM4ECHRM3CHRM2CHRM1 | |
| SCHEMBL3397942 | 0.82 | CHRM3 (0.57) | CHRM3CHRM2CHRM1 | |
| SCHEMBL12062955 | 0.76 | PRMT6 (0.62) | CYP2D6CYP2C19ALDH1A1KDM4ECHRM3 | |
| SCHEMBL4050891 | 0.76 | HRH2 (0.55) | ALOX15CYP2D6CYP2C9TSHRCYP2C19 | |
| SCHEMBL4054843 | 0.76 | KDM4E (0.56) | ALOX15CYP2D6CYP2C9TSHRCYP2C19 | |
| SCHEMBL1631551 | 0.74 | CHRM3 (0.45) | CHRM3CHRM2CHRM1PTGDR2 | |
| SCHEMBL1362848 | 0.74 | CHRM3 (0.48) | CHRM3CHRM2CHRM1 | |
| SCHEMBL3395625 | 0.74 | CHRM3 (0.49) | CHRM3CHRM2CHRM1 | |
| SCHEMBL3397914 | 0.73 | PRMT5 (0.45) | ALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2249647-A1 | DUAL PHARMACOPHORES - PDE4-MUSCARINIC ANTAGONISTICS | Glaxo Group Limited (GB) | 2010-11-17 | — | — | EP | disclosed |
| EP-2249646-A1 | DUAL PHARMACOPHORES - PDE4-MUSCARINIC ANTAGONISTICS | Glaxo Group Limited (GB) | 2010-11-17 | — | — | EP | disclosed |
| WO-2009100168-A1 | DUAL PHARMACOPHORES - PDE4-MUSCARINIC ANTAGONISTICS | GLAXO GROUP LIMITED (GB) | 2009-08-13 | — | — | WO | disclosed |
| WO-2009100169-A1 | DUAL PHARMACOPHORES - PDE4-MUSCARINIC ANTAGONISTICS | GLAXO GROUP LIMITED (GB) | 2009-08-13 | — | — | WO | disclosed |