Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 3/20 | 0.41 |
| ▸ | CTSL | P07711 | 2/20 | 0.40 |
| ▸ | CTSS | P25774 | 2/20 | 0.40 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.39 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.39 |
| ▸ | FPR2 | P25090 | 2/20 | 0.39 |
| ▸ | FPR3 | P25089 | 1/20 | 0.39 |
| ▸ | GPR119 | Q8TDV5 | 6/20 | 0.38 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.36 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | JAK1 | P23458 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3368365 | 1.00 | RORC (0.41) | RORCCTSLCTSSUSP30DGAT1 | |
| SCHEMBL3368358 | 1.00 | RORC (0.41) | RORCCTSLCTSSUSP30DGAT1 | |
| SCHEMBL3368362 | 1.00 | RORC (0.41) | RORCCTSLCTSSUSP30DGAT1 | |
| SCHEMBL4436563 | 1.00 | RORC (0.41) | RORCCTSLCTSSUSP30DGAT1 | |
| SCHEMBL3368383 | 0.84 | RORC (0.51) | RORCUSP30FPR2FPR3GPR119 | |
| SCHEMBL3368376 | 0.84 | RORC (0.51) | RORCUSP30FPR2FPR3GPR119 | |
| SCHEMBL3368381 | 0.84 | RORC (0.51) | RORCUSP30FPR2FPR3GPR119 | |
| SCHEMBL7888577 | 0.83 | GPR119 (0.47) | RORCUSP30GPR119JAK2JAK1 | |
| SCHEMBL3368517 | 0.82 | RORC (0.41) | RORCCTSLCTSSUSP30DGAT1 | |
| SCHEMBL3368520 | 0.82 | RORC (0.41) | RORCCTSLCTSSUSP30DGAT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1646629-B1 | CYCLOPROPYL GROUP SUBSTITUTED OXAZOLIDINONE ANTIBIOTICS AND DERIVATIVES THEREOF | MERCK SHARP & DOHME (US) | 2010-06-23 | — | — | EP | disclosed |