Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 3/20 | 0.40 |
| ▸ | RAB9A | P51151 | 4/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.39 |
| ▸ | NPC1 | O15118 | 4/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | GAA | P10253 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.37 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.37 |
| ▸ | PPARA | Q07869 | 1/20 | 0.36 |
| ▸ | CDC7 | O00311 | 1/20 | 0.36 |
| ▸ | DBF4 | Q9UBU7 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3400809 | 0.92 | TRPM8 (0.39) | CRHR1RAB9ASMN1; SMN2NPC1KDM4E | |
| SCHEMBL3405333 | 0.90 | RAB9A (0.40) | CRHR1RAB9ASMN1; SMN2NPC1KDM4E | |
| SCHEMBL3398655 | 0.87 | TRPM8 (0.47) | RAB9ASMN1; SMN2NPC1KDM4EPOLB | |
| SCHEMBL3401041 | 0.85 | TRPM8 (0.53) | RAB9ASMN1; SMN2NPC1KMT2AALDH1A1 | |
| SCHEMBL3404948 | 0.85 | SMN1; SMN2 (0.56) | CRHR1RAB9ASMN1; SMN2NPC1KDM4E | |
| SCHEMBL3401729 | 0.85 | RAB9A (0.54) | RAB9ASMN1; SMN2NPC1KDM4EPOLB | |
| SCHEMBL3402129 | 0.84 | HTR2C (0.43) | CRHR1RAB9ASMN1; SMN2NPC1KDM4E | |
| SCHEMBL3402280 | 0.84 | CDC7 (0.44) | RAB9ASMN1; SMN2NPC1KDM4EPOLB | |
| SCHEMBL3404718 | 0.83 | KMT2A (0.60) | CRHR1RAB9ASMN1; SMN2NPC1KDM4E | |
| SCHEMBL3402406 | 0.83 | HTR2C (0.40) | CRHR1RAB9ASMN1; SMN2NPC1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| WO-2006089076-A9 | THIAZOLE AMIDES, IMIDAZOLE AMIDES AND RELATED ANALOGUES | NEUROGEN CORP (US) | 2007-04-26 | — | — | WO | disclosed |