Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 8/20 | 0.43 |
| ▸ | RAB9A | P51151 | 4/20 | 0.43 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 3/20 | 0.41 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 4/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3406292 | 0.84 | SMN1; SMN2 (0.54) | SMN1; SMN2RAB9AHSP90AA1MAPTMAPK1 | |
| SCHEMBL3404604 | 0.83 | L3MBTL1 (0.42) | SMN1; SMN2RAB9AHSP90AA1MAPTMAPK1 | |
| SCHEMBL3404610 | 0.82 | SMN1; SMN2 (0.48) | SMN1; SMN2RAB9AHSP90AA1MAPTMAPK1 | |
| SCHEMBL3401762 | 0.81 | AOC3 (0.53) | SMN1; SMN2MAPT | |
| SCHEMBL3406056 | 0.75 | AOC3 (0.48) | SMN1; SMN2RAB9AMAPTNPC1LMNA | |
| SCHEMBL973157 | 0.75 | AOC3 (0.41) | SMN1; SMN2RAB9AHSP90AA1MAPTMAPK1 | |
| SCHEMBL4871149 | 0.71 | CYP1A2 (0.76) | SMN1; SMN2RAB9AHSP90AA1MAPTMAPK1 | |
| SCHEMBL465734 | 0.71 | CYP1A2 (0.67) | SMN1; SMN2RAB9AHSP90AA1MAPTMAPK1 | |
| SCHEMBL3401397 | 0.71 | SMN1; SMN2 (0.43) | SMN1; SMN2RAB9AMAPTMAPK1CYP1A2 | |
| SCHEMBL972198 | 0.71 | AOC3 (0.39) | SMN1; SMN2RAB9AHSP90AA1MAPTMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2252604-A1 | THIAZOLE DERIVATIVE AND USE THEREOF AS VAP-1 INHIBITOR | R-Tech Ueno, Ltd. (JP) | 2010-11-24 | — | — | EP | disclosed |
| WO-2009096609-A1 | THIAZOLE DERIVATIVE AND USE THEREOF AS VAP-1 INHIBITOR | R-TECH UENO, LTD. (JP) | 2009-08-06 | — | — | WO | disclosed |