Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR1 | P21554 | 1/20 | 0.53 |
| ▸ | HTR2C | P28335 | 7/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | THRA | P10827 | 2/20 | 0.47 |
| ▸ | THRB | P10828 | 2/20 | 0.47 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | OXTR | P30559 | 1/20 | 0.43 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13309716 | 0.91 | HRH3 (0.56) | CNR1HTR2CTHRATHRBHRH3 | |
| SCHEMBL3405666 | 0.91 | HRH3 (0.56) | CNR1HTR2CTHRATHRBHRH3 | |
| SCHEMBL3405417 | 0.90 | KMT2A (0.57) | CNR1HTR2CALDH1A1HPGDTHRA | |
| SCHEMBL3398926 | 0.90 | TRPM8 (0.54) | CNR1HTR2CALDH1A1HPGDTHRA | |
| SCHEMBL3405619 | 0.89 | CNR1 (0.48) | CNR1HTR2CALDH1A1HPGDTHRA | |
| SCHEMBL3400921 | 0.89 | CNR1 (0.66) | CNR1HTR2CALDH1A1HPGDHRH3 | |
| SCHEMBL3398454 | 0.89 | MAPK1 (0.51) | CNR1HTR2CALDH1A1HPGDTHRA | |
| SCHEMBL3401828 | 0.89 | HRH3 (0.52) | CNR1HTR2CALDH1A1HPGDTHRA | |
| SCHEMBL3403007 | 0.88 | CNR1 (0.52) | CNR1HTR2CALDH1A1HPGDTHRA | |
| SCHEMBL3404810 | 0.88 | CNR1 (0.49) | CNR1HTR2CALDH1A1HPGDTHRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |