Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.56 |
| ▸ | HTR2C | P28335 | 4/20 | 0.52 |
| ▸ | CNR1 | P21554 | 1/20 | 0.52 |
| ▸ | THRA | P10827 | 2/20 | 0.51 |
| ▸ | THRB | P10828 | 2/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | L3MBTL3 | Q96JM7 | 3/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | OXTR | P30559 | 1/20 | 0.47 |
| ▸ | MBTD1 | Q05BQ5 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13309716 | 1.00 | HRH3 (0.56) | HRH3HTR2CCNR1THRATHRB | |
| SCHEMBL3404795 | 0.91 | CNR1 (0.53) | HRH3HTR2CCNR1THRATHRB | |
| SCHEMBL3403838 | 0.90 | HRH3 (0.67) | HRH3HTR2CCNR1THRATHRB | |
| SCHEMBL3402234 | 0.90 | TDP1 (0.54) | HRH3HTR2CCNR1THRATHRB | |
| SCHEMBL13071715 | 0.90 | HRH3 (0.67) | HRH3HTR2CCNR1THRATHRB | |
| SCHEMBL13072174 | 0.90 | TDP1 (0.54) | HRH3HTR2CCNR1THRATHRB | |
| SCHEMBL3403003 | 0.89 | CNR1 (0.65) | HRH3HTR2CCNR1THRATHRB | |
| SCHEMBL3405391 | 0.89 | CNR1 (0.65) | HRH3HTR2CCNR1THRATHRB | |
| SCHEMBL3404094 | 0.89 | THRA (0.49) | HRH3HTR2CCNR1THRATHRB | |
| SCHEMBL3404149 | 0.89 | THRA (0.49) | HRH3HTR2CCNR1THRATHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| WO-2006089076-A9 | THIAZOLE AMIDES, IMIDAZOLE AMIDES AND RELATED ANALOGUES | NEUROGEN CORP (US) | 2007-04-26 | — | — | WO | disclosed |