Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH2 | P25021 | 1/20 | 0.50 |
| ▸ | HRH1 | P35367 | 1/20 | 0.50 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.47 |
| ▸ | PPARA | Q07869 | 5/20 | 0.46 |
| ▸ | PPARD | Q03181 | 3/20 | 0.46 |
| ▸ | ACHE | P22303 | 1/20 | 0.44 |
| ▸ | CNR1 | P21554 | 1/20 | 0.43 |
| ▸ | CES2 | O00748 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | THRA | P10827 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | LSS | P48449 | 1/20 | 0.40 |
| ▸ | HTR2C | P28335 | 2/20 | 0.39 |
| ▸ | PPARG | P37231 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3405886 | 0.90 | CNR1 (0.43) | HRH2HRH1HRH3ACHECNR1 | |
| SCHEMBL3405513 | 0.89 | HRH3 (0.49) | HRH2HRH1HRH3CNR1ALDH1A1 | |
| SCHEMBL3401187 | 0.88 | NPC1 (0.51) | HRH3PPARAPPARDCNR1CES2 | |
| SCHEMBL3402581 | 0.87 | CNR1 (0.47) | HRH3CNR1CES2ALDH1A1THRA | |
| SCHEMBL3403844 | 0.87 | CNR1 (0.51) | HRH2HRH1HRH3CNR1CES2 | |
| SCHEMBL3402410 | 0.85 | CNR1 (0.47) | HRH3CNR1CES2ALDH1A1THRA | |
| SCHEMBL3401483 | 0.85 | RAB9A (0.49) | HRH2HRH1HRH3CNR1LMNA | |
| SCHEMBL3401176 | 0.85 | CNR1 (0.60) | HRH3CNR1CES2ALDH1A1SMN1; SMN2 | |
| SCHEMBL3402959 | 0.85 | HRH3 (0.46) | HRH2HRH1HRH3CNR1ALDH1A1 | |
| SCHEMBL3399935 | 0.84 | CNR1 (0.46) | HRH3CNR1CES2LMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| WO-2006089076-A9 | THIAZOLE AMIDES, IMIDAZOLE AMIDES AND RELATED ANALOGUES | NEUROGEN CORP (US) | 2007-04-26 | — | — | WO | disclosed |