Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR1 | P21554 | 1/20 | 0.60 |
| ▸ | HTR2C | P28335 | 6/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | CES2 | O00748 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.43 |
| ▸ | PARP1 | P09874 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3403844 | 0.92 | CNR1 (0.51) | CNR1HTR2CSMN1; SMN2HPGDNPC1 | |
| SCHEMBL3402239 | 0.91 | CNR1 (0.49) | CNR1HTR2CSMN1; SMN2HPGDNPC1 | |
| SCHEMBL3405569 | 0.90 | CNR1 (0.48) | CNR1HTR2CALDH1A1MAPTHRH3 | |
| SCHEMBL3402581 | 0.90 | CNR1 (0.47) | CNR1HTR2CHPGDALDH1A1MAPT | |
| SCHEMBL3401483 | 0.90 | RAB9A (0.49) | CNR1SMN1; SMN2NPC1ALDH1A1MAPT | |
| SCHEMBL3402410 | 0.90 | CNR1 (0.47) | CNR1HTR2CHPGDALDH1A1HRH3 | |
| SCHEMBL3400514 | 0.89 | HTR2C (0.48) | CNR1HTR2CHRH3CES2PARP1 | |
| SCHEMBL3405405 | 0.89 | KMT2A (0.53) | CNR1HTR2CNPC1ALDH1A1MAPT | |
| SCHEMBL3404063 | 0.89 | TRPM8 (0.50) | CNR1HTR2CMAPTHRH3CES2 | |
| SCHEMBL3405513 | 0.88 | HRH3 (0.49) | CNR1HTR2CHPGDALDH1A1HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| WO-2006089076-A9 | THIAZOLE AMIDES, IMIDAZOLE AMIDES AND RELATED ANALOGUES | NEUROGEN CORP (US) | 2007-04-26 | — | — | WO | disclosed |