Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 6/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | TRPM8 | Q7Z2W7 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | PPARA | Q07869 | 1/20 | 0.35 |
| ▸ | PARP1 | P09874 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3401198 | 0.92 | HTR2C (0.47) | HTR2CLMNAALDH1A1NPSR1TRPM8 | |
| SCHEMBL3400428 | 0.89 | LMNA (0.39) | HTR2CLMNAALDH1A1NPSR1TRPM8 | |
| SCHEMBL3402113 | 0.89 | HTR2C (0.47) | HTR2CLMNAALDH1A1NPSR1TRPM8 | |
| SCHEMBL3402386 | 0.89 | HTR2C (0.49) | HTR2CLMNAALDH1A1NPSR1TRPM8 | |
| SCHEMBL3400942 | 0.85 | HTR2C (0.49) | HTR2CALDH1A1TRPM8MEN1KMT2A | |
| SCHEMBL3404998 | 0.83 | HTR2C (0.47) | HTR2CALDH1A1TRPM8MEN1KMT2A | |
| SCHEMBL3399563 | 0.82 | HTR2C (0.43) | HTR2CALDH1A1TRPM8MEN1KMT2A | |
| SCHEMBL13071984 | 0.82 | HTR2C (0.40) | HTR2CALDH1A1TRPM8L3MBTL1RAB9A | |
| SCHEMBL3403609 | 0.82 | HTR2C (0.62) | HTR2CLMNAALDH1A1TRPM8RAB9A | |
| SCHEMBL3400771 | 0.81 | HTR2C (0.45) | HTR2CALDH1A1TRPM8MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| WO-2006089076-A9 | THIAZOLE AMIDES, IMIDAZOLE AMIDES AND RELATED ANALOGUES | NEUROGEN CORP (US) | 2007-04-26 | — | — | WO | disclosed |