Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARA | Q07869 | 6/20 | 0.52 |
| ▸ | PPARD | Q03181 | 3/20 | 0.52 |
| ▸ | PPARG | P37231 | 2/20 | 0.52 |
| ▸ | GAA | P10253 | 4/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | CHRM4 | P08173 | 3/20 | 0.51 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | DRD2 | P14416 | 1/20 | 0.44 |
| ▸ | DRD3 | P35462 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3399440 | 0.91 | CHRM4 (0.62) | PPARAPPARDPPARGGAAMAPT | |
| SCHEMBL3398627 | 0.88 | CHRM4 (0.60) | PPARAPPARDGAAMAPTALDH1A1 | |
| SCHEMBL3404930 | 0.87 | CHRM4 (0.48) | GAAMAPTALDH1A1SMN1; SMN2CHRM4 | |
| SCHEMBL3404897 | 0.86 | ACHE (0.54) | PPARAPPARDGAAMAPTALDH1A1 | |
| SCHEMBL3400105 | 0.85 | HRH3 (0.53) | GAACHRM4NPC1HPGDDRD3 | |
| SCHEMBL3403571 | 0.85 | PPARA (0.58) | PPARAPPARDPPARGGAAALDH1A1 | |
| SCHEMBL3399687 | 0.85 | CHRM4 (0.52) | PPARAGAAMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL3403462 | 0.84 | CHRM4 (0.65) | PPARAPPARDPPARGGAAMAPT | |
| SCHEMBL3399330 | 0.84 | KCNH2 (0.51) | GAAMAPTSMN1; SMN2CHRM4NPC1 | |
| SCHEMBL3403357 | 0.83 | DRD3 (0.49) | GAALMNACHRM4NPC1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| WO-2006089076-A9 | THIAZOLE AMIDES, IMIDAZOLE AMIDES AND RELATED ANALOGUES | NEUROGEN CORP (US) | 2007-04-26 | — | — | WO | disclosed |