Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 1/20 | 0.54 |
| ▸ | PPARA | Q07869 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 5/20 | 0.51 |
| ▸ | THRB | P10828 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | DRD3 | P35462 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | PPARD | Q03181 | 1/20 | 0.47 |
| ▸ | SMYD2 | Q9NRG4 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3398904 | 0.92 | POLB (0.60) | ACHEPPARAMAPTTHRBPOLB | |
| SCHEMBL3401183 | 0.92 | MAPT (0.49) | ACHEPPARAMAPTTHRBPOLB | |
| SCHEMBL3399687 | 0.90 | CHRM4 (0.52) | ACHEPPARAMAPTGAAALDH1A1 | |
| SCHEMBL3403571 | 0.89 | PPARA (0.58) | PPARAGAAALDH1A1CHRM4PPARD | |
| SCHEMBL3401121 | 0.89 | AGER (0.47) | ACHEMAPTTHRBALDH1A1CHRM4 | |
| SCHEMBL3398627 | 0.88 | CHRM4 (0.60) | PPARAMAPTPOLBGAAALDH1A1 | |
| SCHEMBL3404930 | 0.87 | CHRM4 (0.48) | MAPTTHRBDRD3GAAALDH1A1 | |
| SCHEMBL3405022 | 0.86 | PPARA (0.52) | PPARAMAPTDRD3GAAALDH1A1 | |
| SCHEMBL3399330 | 0.86 | KCNH2 (0.51) | MAPTTHRBGAACHRM4 | |
| SCHEMBL3403357 | 0.85 | DRD3 (0.49) | DRD3GAACYP1A2CYP3A4CHRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| WO-2006089076-A9 | THIAZOLE AMIDES, IMIDAZOLE AMIDES AND RELATED ANALOGUES | NEUROGEN CORP (US) | 2007-04-26 | — | — | WO | disclosed |