Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 12/20 | 0.67 |
| ▸ | TP53 | P04637 | 4/20 | 0.61 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | GBA1 | P04062 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | USP2 | O75604 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | CASP1 | P29466 | 1/20 | 0.49 |
| ▸ | PPARG | P37231 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.49 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3402289 | 0.91 | GRM5 (0.67) | GRM5TP53PTGS2SMN1; SMN2NPC1 | |
| SCHEMBL30387819 | 0.91 | GRM5 (0.58) | GRM5TP53SMN1; SMN2GBA1MAPT | |
| SCHEMBL20604169 | 0.91 | GRM5 (0.58) | GRM5TP53SMN1; SMN2GBA1MAPT | |
| SCHEMBL3401188 | 0.89 | TP53 (0.59) | GRM5TP53PTGS2SMN1; SMN2MAPT | |
| SCHEMBL8000300 | 0.87 | GRM5 (0.69) | GRM5TP53PTGS2SMN1; SMN2NPC1 | |
| SCHEMBL7987917 | 0.85 | TP53 (0.57) | GRM5TP53PTGS2SMN1; SMN2MAPT | |
| SCHEMBL3402699 | 0.83 | TP53 (0.57) | GRM5TP53PTGS2SMN1; SMN2MAPT | |
| SCHEMBL7996185 | 0.81 | GRM5 (0.61) | GRM5NPC1RAB9AMAPTRIPK1 | |
| SCHEMBL3435510 | 0.81 | TP53 (0.57) | GRM5TP53PTGS2SMN1; SMN2NPC1 | |
| SCHEMBL24695901 | 0.80 | GSK3B (0.72) | GRM5NPC1RAB9ARIPK1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2252599-A1 | TRIAZOLE AMIDE DERIVATIVES FOR USE IN THERAPY | Glaxo Group Limited (GB) | 2010-11-24 | — | — | EP | claimed |
| WO-2009115486-A1 | TRIAZOLE AMIDE DERIVATIVES FOR USE IN THERAPY | GLAXO GROUP LIMITED (GB) | 2009-09-24 | — | — | WO | claimed |
| EP-2252599-A1 | TRIAZOLE AMIDE DERIVATIVES FOR USE IN THERAPY | Glaxo Group Limited (GB) | 2010-11-24 | — | — | EP | disclosed |
| WO-2009115486-A1 | TRIAZOLE AMIDE DERIVATIVES FOR USE IN THERAPY | GLAXO GROUP LIMITED (GB) | 2009-09-24 | — | — | WO | disclosed |
| WO-2009115486-A1 | TRIAZOLE AMIDE DERIVATIVES FOR USE IN THERAPY | GLAXO GROUP LIMITED (GB) | 2009-09-24 | — | — | WO | disclosed |