Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 3/20 | 0.59 |
| ▸ | GRM5 | P41594 | 8/20 | 0.57 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | SMURF1 | Q9HCE7 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | CCR1 | P32246 | 1/20 | 0.48 |
| ▸ | GSK3B | P49841 | 1/20 | 0.46 |
| ▸ | WNT3A | P56704 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3402289 | 0.89 | GRM5 (0.67) | TP53GRM5PTGS2SMN1; SMN2SMURF1 | |
| SCHEMBL3405207 | 0.89 | GRM5 (0.67) | TP53GRM5PTGS2SMN1; SMN2MAPT | |
| SCHEMBL8000300 | 0.85 | GRM5 (0.69) | TP53GRM5PTGS2SMN1; SMN2SMURF1 | |
| SCHEMBL3433965 | 0.81 | TP53 (0.55) | TP53GRM5PTGS2SMN1; SMN2SMURF1 | |
| SCHEMBL3398194 | 0.81 | TP53 (0.55) | TP53GRM5PTGS2SMN1; SMN2SMURF1 | |
| SCHEMBL3402699 | 0.81 | TP53 (0.57) | TP53GRM5PTGS2SMN1; SMN2SMURF1 | |
| SCHEMBL3407265 | 0.80 | MAPT (0.65) | TP53PTGS2SMN1; SMN2SMURF1MAPT | |
| SCHEMBL30387819 | 0.79 | GRM5 (0.58) | TP53GRM5SMN1; SMN2MAPTGSK3B | |
| SCHEMBL20604169 | 0.79 | GRM5 (0.58) | TP53GRM5SMN1; SMN2MAPTGSK3B | |
| SCHEMBL7987917 | 0.79 | TP53 (0.57) | TP53GRM5PTGS2SMN1; SMN2SMURF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2252599-A1 | TRIAZOLE AMIDE DERIVATIVES FOR USE IN THERAPY | Glaxo Group Limited (GB) | 2010-11-24 | — | — | EP | claimed |
| WO-2009115486-A1 | TRIAZOLE AMIDE DERIVATIVES FOR USE IN THERAPY | GLAXO GROUP LIMITED (GB) | 2009-09-24 | — | — | WO | claimed |
| EP-2252599-A1 | TRIAZOLE AMIDE DERIVATIVES FOR USE IN THERAPY | Glaxo Group Limited (GB) | 2010-11-24 | — | — | EP | disclosed |
| WO-2009115486-A1 | TRIAZOLE AMIDE DERIVATIVES FOR USE IN THERAPY | GLAXO GROUP LIMITED (GB) | 2009-09-24 | — | — | WO | disclosed |
| WO-2009115486-A1 | TRIAZOLE AMIDE DERIVATIVES FOR USE IN THERAPY | GLAXO GROUP LIMITED (GB) | 2009-09-24 | — | — | WO | disclosed |