Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 4/20 | 0.57 |
| ▸ | PTGS2 | P35354 | 5/20 | 0.56 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | GRM5 | P41594 | 4/20 | 0.48 |
| ▸ | MET | P08581 | 3/20 | 0.46 |
| ▸ | SMURF1 | Q9HCE7 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3405207 | 0.85 | GRM5 (0.67) | TP53PTGS2MAPTSMN1; SMN2GRM5 | |
| SCHEMBL3402289 | 0.81 | GRM5 (0.67) | TP53PTGS2MAPTSMN1; SMN2GRM5 | |
| SCHEMBL3402699 | 0.80 | TP53 (0.57) | TP53PTGS2MAPTSMN1; SMN2GRM5 | |
| SCHEMBL3435510 | 0.80 | TP53 (0.57) | TP53PTGS2MAPTSMN1; SMN2GRM5 | |
| SCHEMBL3401188 | 0.79 | TP53 (0.59) | TP53PTGS2MAPTSMN1; SMN2GRM5 | |
| SCHEMBL7997003 | 0.78 | TP53 (0.55) | TP53PTGS2MAPTSMN1; SMN2MET | |
| SCHEMBL13754541 | 0.78 | PTGS2 (0.71) | TP53PTGS2MAPTSMN1; SMN2MET | |
| SCHEMBL8000300 | 0.77 | GRM5 (0.69) | TP53PTGS2MAPTSMN1; SMN2GRM5 | |
| SCHEMBL3398194 | 0.76 | TP53 (0.55) | TP53PTGS2MAPTSMN1; SMN2GRM5 | |
| SCHEMBL20604169 | 0.75 | GRM5 (0.58) | TP53MAPTSMN1; SMN2GRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009115486-A1 | TRIAZOLE AMIDE DERIVATIVES FOR USE IN THERAPY | GLAXO GROUP LIMITED (GB) | 2009-09-24 | — | — | WO | disclosed |