Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.44 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.43 |
| ▸ | RAD52 | P43351 | 1/20 | 0.43 |
| ▸ | GRK5 | P34947 | 1/20 | 0.43 |
| ▸ | GSK3A | P49840 | 1/20 | 0.43 |
| ▸ | GSK3B | P49841 | 1/20 | 0.43 |
| ▸ | AVPR1B | P47901 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3399919 | 0.99 | HPGD (0.46) | MKNK2NPC1HPGDROCK1SCN9A | |
| SCHEMBL3405815 | 0.91 | MAPT (0.52) | NPC1HPGDROCK1MAPTKDM4E | |
| SCHEMBL3429141 | 0.89 | GLA (0.50) | NPC1HPGDSCN9AMAPTKDM4E | |
| SCHEMBL3429158 | 0.88 | GLA (0.51) | NPC1HPGDSCN9AMAPTKDM4E | |
| SCHEMBL3399733 | 0.88 | GLS (0.48) | NPC1HPGDSCN9AMAPTALDH1A1 | |
| SCHEMBL3398475 | 0.86 | PPARA (0.49) | NPC1HPGDSCN9AMAPTALDH1A1 | |
| SCHEMBL3403919 | 0.85 | ACKR3 (0.51) | NPC1HPGDROCK1MAPTCHRM4 | |
| SCHEMBL3405410 | 0.83 | HPGD (0.47) | NPC1HPGDSCN9AMAPTKDM4E | |
| SCHEMBL3398806 | 0.83 | CHRM4 (0.54) | NPC1HPGDSCN9AMAPTALDH1A1 | |
| SCHEMBL3400541 | 0.83 | HPGD (0.48) | NPC1HPGDMAPTALDH1A1CHRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |