Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARA | Q07869 | 4/20 | 0.49 |
| ▸ | PPARD | Q03181 | 2/20 | 0.49 |
| ▸ | GLS | O94925 | 1/20 | 0.47 |
| ▸ | CHRM4 | P08173 | 3/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | ACP1 | P24666 | 1/20 | 0.44 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | RAD52 | P43351 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.42 |
| ▸ | ABL1 | P00519 | 1/20 | 0.42 |
| ▸ | BCR | P11274 | 1/20 | 0.42 |
| ▸ | PPARG | P37231 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3399733 | 0.99 | GLS (0.48) | PPARAPPARDGLSCHRM4NPC1 | |
| SCHEMBL3404144 | 0.94 | PPARA (0.47) | PPARAPPARDGLSCHRM4NPC1 | |
| SCHEMBL3405815 | 0.90 | MAPT (0.52) | NPC1HPGDMAPTRAD52LMNA | |
| SCHEMBL3401424 | 0.89 | PPARA (0.61) | PPARAPPARDCHRM4NPC1SCN9A | |
| SCHEMBL3405464 | 0.88 | PPARA (0.60) | PPARAPPARDCHRM4NPC1SCN9A | |
| SCHEMBL3399919 | 0.87 | HPGD (0.46) | PPARACHRM4NPC1HPGDSCN9A | |
| SCHEMBL3429158 | 0.87 | GLA (0.51) | CHRM4NPC1HPGDSCN9AMAPT | |
| SCHEMBL3398440 | 0.87 | ACKR3 (0.51) | PPARAPPARDCHRM4NPC1HPGD | |
| SCHEMBL3429141 | 0.86 | GLA (0.50) | CHRM4NPC1HPGDSCN9AMAPT | |
| SCHEMBL3405546 | 0.86 | MKNK2 (0.46) | CHRM4NPC1HPGDSCN9AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| WO-2006089076-A9 | THIAZOLE AMIDES, IMIDAZOLE AMIDES AND RELATED ANALOGUES | NEUROGEN CORP (US) | 2007-04-26 | — | — | WO | disclosed |