Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 5/20 | 0.35 |
| ▸ | NPC1 | O15118 | 4/20 | 0.35 |
| ▸ | LMNA | P02545 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 8/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.33 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 2/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3394855 | 0.86 | KDM4E (0.30) | RAB9ANPC1SMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL5954339 | 0.82 | KDM4E (0.38) | RAB9ANPC1LMNAKMT2AMEN1 | |
| SCHEMBL253680 | 0.79 | CSNK1D (0.44) | RAB9ANPC1SMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL253551 | 0.79 | SMN1; SMN2 (0.40) | LMNASMN1; SMN2KDM4EALDH1A1CSNK1D | |
| SCHEMBL252283 | 0.77 | RAB9A (0.41) | RAB9ANPC1LMNAKMT2AMEN1 | |
| SCHEMBL251711 | 0.76 | CSNK1D (0.53) | KMT2AKDM4EALDH1A1CSNK1DCSNK1E | |
| SCHEMBL3405752 | 0.69 | PIK3CA (0.32) | — | |
| SCHEMBL5953672 | 0.68 | KDM4E (0.30) | RAB9ANPC1SMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL5954590 | 0.66 | JAK1 (0.48) | RAB9ANPC1CSNK1DCSNK1E | |
| SCHEMBL5955071 | 0.65 | KDR (0.44) | CSNK1DCSNK1E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012003338-A1 | COMBINATION OF A cMET INHIBITOR AND AN ANTIBODY TO HGF AND/OR cMET | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-01-05 | — | — | WO | disclosed |
| WO-2010019899-A1 | cMET INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-02-18 | — | — | WO | disclosed |