Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM4 | P08173 | 4/20 | 0.56 |
| ▸ | ACKR3 | P25106 | 2/20 | 0.49 |
| ▸ | PPARA | Q07869 | 5/20 | 0.48 |
| ▸ | PPARD | Q03181 | 2/20 | 0.48 |
| ▸ | LCK | P06239 | 1/20 | 0.48 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.44 |
| ▸ | PANK3 | Q9H999 | 1/20 | 0.41 |
| ▸ | HTR2C | P28335 | 2/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | JAK1 | P23458 | 1/20 | 0.40 |
| ▸ | POLR1A | O95602 | 1/20 | 0.40 |
| ▸ | PPARG | P37231 | 1/20 | 0.40 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3401222 | 0.93 | CHRM4 (0.56) | CHRM4ACKR3PPARAPPARDLCK | |
| SCHEMBL3400900 | 0.85 | CHRM4 (0.54) | CHRM4ACKR3PPARAPPARDLCK | |
| SCHEMBL3400884 | 0.85 | CHRM4 (0.54) | CHRM4ACKR3PPARAPPARDLCK | |
| SCHEMBL3402294 | 0.84 | CHRM4 (0.56) | CHRM4ACKR3PPARAPPARDLCK | |
| SCHEMBL3401250 | 0.84 | PDE2A (0.47) | CHRM4PPARAPPARDPANK3HTR2C | |
| SCHEMBL3405526 | 0.84 | PPARD (0.53) | CHRM4ACKR3PPARAPPARDCHRM3 | |
| SCHEMBL3400106 | 0.84 | ACKR3 (0.52) | CHRM4ACKR3PPARAPPARDLCK | |
| SCHEMBL3405595 | 0.83 | PDE2A (0.47) | CHRM4PPARAPPARDPANK3HTR2C | |
| SCHEMBL3404854 | 0.83 | DRD2 (0.52) | ACKR3PPARAPPARD | |
| SCHEMBL3402461 | 0.83 | CHRM4 (0.55) | CHRM4ACKR3PPARAPPARDLCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |