Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 2/20 | 0.49 |
| ▸ | HTR1A | P08908 | 1/20 | 0.49 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.49 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.49 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.49 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.49 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.49 |
| ▸ | DRD1 | P21728 | 1/20 | 0.45 |
| ▸ | DRD4 | P21917 | 1/20 | 0.45 |
| ▸ | DRD5 | P21918 | 1/20 | 0.45 |
| ▸ | DRD3 | P35462 | 1/20 | 0.45 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.45 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.45 |
| ▸ | SLC18A3 | Q16572 | 3/20 | 0.45 |
| ▸ | USP5 | P45974 | 1/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.41 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL27854009 | 0.98 | DRD2 (0.47) | DRD2HTR1ACHRNB2CHRNB4CHRNA3 | |
| SCHEMBL27749604 | 0.98 | DRD2 (0.50) | DRD2HTR1ACHRNB2CHRNB4CHRNA3 | |
| Formamide SCHEMBL27459446 | 0.88 | DRD2 (0.42) | DRD2HTR1ACHRNB2CHRNB4CHRNA3 | |
| SCHEMBL23978388 | 0.81 | SLC18A3 (0.43) | DRD2SLC18A3KMT2A | |
| SCHEMBL2089824 | 0.80 | CHRNA7 (0.59) | DRD2HTR1ACHRNB2CHRNB4CHRNA3 | |
| SCHEMBL7736890 | 0.79 | BRD4 (0.46) | DRD2HTR1ACHRNB2CHRNB4CHRNA3 | |
| SCHEMBL14877490 | 0.79 | BRD4 (0.46) | DRD2HTR1ACHRNB2CHRNB4CHRNA3 | |
| SCHEMBL13481229 | 0.79 | BRD4 (0.46) | DRD2HTR1ACHRNB2CHRNB4CHRNA3 | |
| SCHEMBL1424708 | 0.79 | DRD2 (0.57) | DRD2HTR1ADRD1DRD4DRD5 | |
| SCHEMBL5756822 | 0.79 | SLC6A4 (0.57) | DRD2HTR1ACYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020021015-A1 | NEW IMIDAZOPYRIDINE DERIVATIVES FOR TREATING PAIN AND PAIN RELATED CONDITIONS | ESTEVE PHARMACEUTICALS, S.A. (ES) | 2020-01-30 | — | — | WO | claimed |
| CN-102015683-B | The indole derivatives replaced | GRUNENTHAL GMBH (DE) | 2015-08-05 | — | — | CN | claimed |
| CN-102015683-A | Substituted indole derivatives | GRUENENTHAL GMBH | 2011-04-13 | — | — | CN | claimed |
| EP-2254883-A1 | SUBSTITUTED INDOLE DERIVATIVES | Grünenthal GmbH (DE) | 2010-12-01 | — | — | EP | claimed |
| WO-2009103552-A1 | SUBSTITUTED INDOLE DERIVATIVES | Grünenthal GmbH (DE) | 2009-08-27 | — | — | WO | claimed |
| CN-102015683-B | The indole derivatives replaced | GRUNENTHAL GMBH (DE) | 2015-08-05 | — | — | CN | disclosed |
| EP-2254883-B1 | SUBSTITUTED INDOLE DERIVATIVES | GRUENENTHAL GMBH (DE) | 2014-11-26 | — | — | EP | disclosed |
| CN-102015683-A | Substituted indole derivatives | GRUENENTHAL GMBH | 2011-04-13 | — | — | CN | disclosed |
| EP-2254883-A1 | SUBSTITUTED INDOLE DERIVATIVES | Grünenthal GmbH (DE) | 2010-12-01 | — | — | EP | disclosed |
| WO-2009103552-A1 | SUBSTITUTED INDOLE DERIVATIVES | Grünenthal GmbH (DE) | 2009-08-27 | — | — | WO | disclosed |