Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK9 | P50750 | 14/20 | 0.39 |
| ▸ | CCNT1 | O60563 | 9/20 | 0.39 |
| ▸ | PARP1 | P09874 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | CDK2 | P24941 | 7/20 | 0.36 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.36 |
| ▸ | IGF1R | P08069 | 2/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | RET | P07949 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | AURKA | O14965 | 1/20 | 0.36 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.36 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.35 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3411154 | 0.88 | PSEN1 (0.43) | CDK9CCNT1CDK2IGF1RRET | |
| SCHEMBL3409536 | 0.85 | RET (0.40) | CDK9CCNT1PARP1KDRCDK2 | |
| SCHEMBL3409757 | 0.84 | CDK9 (0.47) | CDK9CCNT1CDK2CCNA2BRD4 | |
| SCHEMBL3410466 | 0.84 | PSEN1 (0.43) | CDK9CCNT1CDK2IGF1RRET | |
| SCHEMBL3408509 | 0.82 | CDK9 (0.40) | CDK9CCNT1PARP1KDRCDK2 | |
| SCHEMBL3412794 | 0.81 | SYK (0.39) | CDK9CCNT1CDK2CCNA2RET | |
| SCHEMBL3410131 | 0.80 | CCNA2 (0.37) | CDK9CCNT1KDRCDK2CCNA2 | |
| SCHEMBL3412591 | 0.79 | CDK9 (0.42) | CDK9CCNT1PARP1KDRCDK2 | |
| SCHEMBL3406878 | 0.79 | SYK (0.50) | — | |
| SCHEMBL3406106 | 0.79 | IGF1R (0.41) | CDK9CCNT1PARP1KDRCDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2257541-A1 | MODULATORS FOR AMYLOID BETA | F. Hoffmann-La Roche AG (CH) | 2010-12-08 | — | — | EP | disclosed |
| WO-2009103652-A1 | MODULATORS FOR AMYLOID BETA | F. HOFFMANN-LA ROCHE AG (CH) | 2009-08-27 | — | — | WO | disclosed |