Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 1/20 | 0.40 |
| ▸ | IGF1R | P08069 | 8/20 | 0.40 |
| ▸ | CDK9 | P50750 | 4/20 | 0.40 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.40 |
| ▸ | AURKA | O14965 | 3/20 | 0.40 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.40 |
| ▸ | KDR | P35968 | 2/20 | 0.39 |
| ▸ | BRD4 | O60885 | 2/20 | 0.39 |
| ▸ | CDK2 | P24941 | 3/20 | 0.38 |
| ▸ | CDK4 | P11802 | 2/20 | 0.38 |
| ▸ | CDK1 | P06493 | 2/20 | 0.38 |
| ▸ | CDK7 | P50613 | 2/20 | 0.38 |
| ▸ | PARP1 | P09874 | 1/20 | 0.37 |
| ▸ | GSK3B | P49841 | 1/20 | 0.37 |
| ▸ | PLK1 | P53350 | 1/20 | 0.37 |
| ▸ | SYK | P43405 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3408338 | 0.89 | NPC1 (0.40) | PLK1 | |
| SCHEMBL3408509 | 0.89 | CDK9 (0.40) | RETIGF1RCDK9CCNT1AURKA | |
| SCHEMBL3411154 | 0.87 | PSEN1 (0.43) | RETIGF1RCDK9CCNT1AURKA | |
| SCHEMBL3410131 | 0.86 | CCNA2 (0.37) | RETIGF1RCDK9CCNT1AURKA | |
| SCHEMBL3412591 | 0.86 | CDK9 (0.42) | RETIGF1RCDK9CCNT1AURKA | |
| SCHEMBL3406434 | 0.85 | CDK9 (0.39) | RETIGF1RCDK9CCNT1AURKA | |
| SCHEMBL3412646 | 0.84 | SYK (0.46) | RETIGF1RCDK9CCNT1AURKA | |
| SCHEMBL3410492 | 0.84 | SYK (0.40) | RETIGF1RCDK9CCNT1AURKA | |
| SCHEMBL3410466 | 0.83 | PSEN1 (0.43) | RETIGF1RCDK9CCNT1AURKA | |
| SCHEMBL3406878 | 0.83 | SYK (0.50) | SYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2257541-A1 | MODULATORS FOR AMYLOID BETA | F. Hoffmann-La Roche AG (CH) | 2010-12-08 | — | — | EP | disclosed |
| WO-2009103652-A1 | MODULATORS FOR AMYLOID BETA | F. HOFFMANN-LA ROCHE AG (CH) | 2009-08-27 | — | — | WO | disclosed |