Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | MELK | Q14680 | 1/20 | 0.49 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.48 |
| ▸ | F2 | P00734 | 1/20 | 0.47 |
| ▸ | PLG | P00747 | 1/20 | 0.47 |
| ▸ | PLAU | P00749 | 1/20 | 0.47 |
| ▸ | PLAT | P00750 | 1/20 | 0.47 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.47 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.47 |
| ▸ | BPTF | Q12830 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL1187882 | 0.99 | MAPT (0.51) | MAPTRAB9ASMN1; SMN2MELKSLC2A1 | |
| Hydrochloric Acid SCHEMBL1187654 | 0.81 | KMT2A (0.55) | MAPTRAB9ASMN1; SMN2SLC2A1F2 | |
| Hydrochloric Acid SCHEMBL1188323 | 0.78 | NPC1 (0.65) | MAPTRAB9ASMN1; SMN2MELKSLC2A1 | |
| Hydrochloric Acid SCHEMBL1189475 | 0.78 | RAB9A (0.55) | RAB9ASMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL1188393 | 0.77 | NPC1 (0.66) | MAPTRAB9ASMN1; SMN2MELKSLC2A1 | |
| Hydrochloric Acid SCHEMBL1189422 | 0.77 | SLC2A1 (0.49) | RAB9AMELKSLC2A1F2PLG | |
| SCHEMBL5455666 | 0.77 | MELK (0.58) | RAB9AMELKF2PLGPLAU | |
| SCHEMBL30568974 | 0.77 | KCNQ3 (0.64) | RAB9ASMN1; SMN2 | |
| SCHEMBL6361424 | 0.77 | KCNQ3 (0.64) | RAB9ASMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL1188061 | 0.76 | POLB (0.67) | RAB9AMELKSLC2A1F2PLG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2256105-B1 | NOVEL TETRAHYDROISOQUINOLINE DERIVATIVE | DAIICHI SANKYO CO LTD (JP) | 2013-12-04 | — | — | EP | disclosed |
| EP-2256105-A1 | NOVEL TETRAHYDROISOQUINOLINE DERIVATIVE | Daiichi Sankyo Company, Limited (JP) | 2010-12-01 | — | — | EP | disclosed |