Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.37 |
| ▸ | BRD4 | O60885 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.33 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.33 |
| ▸ | CASP1 | P29466 | 1/20 | 0.33 |
| ▸ | CASP7 | P55210 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3070792 | 0.93 | KDM4E (0.50) | KDM4ELMNABRD4TP53MAPT | |
| SCHEMBL3065506 | 0.87 | KDM4E (0.34) | KDM4EBRD4MAPTALDH1A1GAA | |
| SCHEMBL3062324 | 0.84 | TP53 (0.43) | KDM4ELMNATP53MAPTALDH1A1 | |
| SCHEMBL3060419 | 0.84 | TP53 (0.43) | KDM4ELMNATP53MAPTALDH1A1 | |
| SCHEMBL3060648 | 0.82 | KDM4E (0.33) | KDM4EBRD4MAPTALDH1A1GAA | |
| SCHEMBL3072587 | 0.82 | ACSS2 (0.42) | KDM4EMAPTALDH1A1GAAMEN1 | |
| SCHEMBL3055685 | 0.80 | MAPT (0.49) | KDM4ELMNATP53MAPTALDH1A1 | |
| SCHEMBL3060459 | 0.80 | MAPT (0.39) | KDM4ETP53MAPTALDH1A1GAA | |
| SCHEMBL3065922 | 0.80 | RPS6KA5 (0.42) | KDM4EMAPTALDH1A1GAAHPGD | |
| SCHEMBL3060232 | 0.80 | CYP11B2 (0.50) | KDM4EBRD4MAPTALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1368342-B3 | BENZIMIDAZOLE AND PYRIDYLIMIDAZOLE DERIVATIVES AS LIGANDS FOR GABA RECEPTORS | NEUROGEN CORP (US) | 2010-12-01 | — | — | EP | claimed |
| EP-1368342-B1 | BENZIMIDAZOLE AND PYRIDYLIMIDAZOLE DERIVATIVES AS LIGANDS FOR GABA RECEPTORS | NEUROGEN CORP (US) | 2005-09-07 | — | — | EP | claimed |