Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 1/20 | 0.40 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.39 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.38 |
| ▸ | AURKA | O14965 | 1/20 | 0.38 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.38 |
| ▸ | RPS6KA4 | O75676 | 1/20 | 0.38 |
| ▸ | KIT | P10721 | 1/20 | 0.38 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.38 |
| ▸ | CDK2 | P24941 | 1/20 | 0.38 |
| ▸ | FLT3 | P36888 | 1/20 | 0.38 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.38 |
| ▸ | RPS6KA2 | Q15349 | 1/20 | 0.38 |
| ▸ | RPS6KA1 | Q15418 | 1/20 | 0.38 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.38 |
| ▸ | RPS6KB2 | Q9UBS0 | 1/20 | 0.38 |
| ▸ | RPS6KA6 | Q9UK32 | 1/20 | 0.38 |
| ▸ | ENPP2 | Q13822 | 2/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | MERTK | Q12866 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2246087 | 0.89 | GPR119 (0.48) | GPR119 | |
| SCHEMBL2250016 | 0.87 | GPR119 (0.42) | NAMPTHSP90AA1CHEK1AURKARPS6KA5 | |
| SCHEMBL2249737 | 0.86 | FLT3 (0.40) | HSP90AA1CHEK1AURKARPS6KA5RPS6KA4 | |
| SCHEMBL3405712 | 0.83 | HSP90AA1 (0.41) | NAMPTHSP90AA1ALDH1A1L3MBTL1GPR119 | |
| SCHEMBL2243836 | 0.82 | GPR119 (0.51) | HSP90AA1CHEK1AURKARPS6KA5RPS6KA4 | |
| SCHEMBL2252146 | 0.79 | GPR119 (0.53) | HSP90AA1CHEK1AURKARPS6KA5RPS6KA4 | |
| SCHEMBL2248689 | 0.79 | ALDH1A1 (0.39) | NAMPTAURKACDK2ENPP2MAPK1 | |
| SCHEMBL2248693 | 0.77 | ALDH1A1 (0.37) | HSP90AA1AURKACDK2ENPP2ALDH1A1 | |
| SCHEMBL21656758 | 0.76 | HSP90AA1 (0.48) | HSP90AA1CHEK1AURKARPS6KA5RPS6KA4 | |
| SCHEMBL2243447 | 0.73 | GPR119 (0.52) | GPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2252613-A1 | COMPOUNDS AND COMPOSITIONS AS MODULATORS OF GPR119 ACTIVITY | IRM, LLC (BM) | 2010-11-24 | — | — | EP | disclosed |
| WO-2009105717-A1 | COMPOUNDS AND COMPOSITIONS AS MODULATORS OF GPR119 ACTIVITY | IRM LLC (BM) | 2009-08-27 | — | — | WO | disclosed |