Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NNMT | P40261 | 7/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | F7 | P08709 | 1/20 | 0.44 |
| ▸ | F3 | P13726 | 1/20 | 0.44 |
| ▸ | SARM1 | Q6SZW1 | 1/20 | 0.44 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.44 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.44 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.44 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.44 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.44 |
| ▸ | SIRT4 | Q9Y6E7 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | PARP1 | P09874 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3407187 | 0.90 | NNMT (0.48) | NNMTSMN1; SMN2L3MBTL1KDM4EF7 | |
| SCHEMBL3141529 | 0.83 | NNMT (0.58) | NNMTSMN1; SMN2L3MBTL1KDM4EF7 | |
| SCHEMBL1745778 | 0.83 | NNMT (0.52) | NNMTSMN1; SMN2L3MBTL1KDM4EF7 | |
| SCHEMBL669121 | 0.83 | NNMT (0.52) | NNMTSMN1; SMN2L3MBTL1KDM4EF7 | |
| SCHEMBL23193160 | 0.81 | NNMT (0.50) | NNMTSMN1; SMN2L3MBTL1KDM4EF7 | |
| SCHEMBL1968189 | 0.81 | NNMT (0.50) | NNMTSMN1; SMN2L3MBTL1KDM4EF7 | |
| SCHEMBL17294856 | 0.79 | NNMT (0.44) | NNMTSMN1; SMN2L3MBTL1KDM4E | |
| SCHEMBL1244783 | 0.79 | SMN1; SMN2 (0.56) | NNMTSMN1; SMN2L3MBTL1KDM4ETSHR | |
| SCHEMBL30033603 | 0.79 | AR (0.49) | NNMTSMN1; SMN2L3MBTL1KDM4EF7 | |
| SCHEMBL4499172 | 0.76 | NNMT (0.46) | NNMTSMN1; SMN2L3MBTL1F7F3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2257539-A1 | SUBSTITUTED 4-HYDROXYPYRIMIDINE-5-CARBOXAMIDES | Merck Sharp & Dohme Corp. (US) | 2010-12-08 | — | — | EP | disclosed |
| WO-2009117269-A1 | SUBSTITUTED 4-HYDROXYPYRIMIDINE-5-CARBOXAMIDES | MERCK & CO., INC. (US) | 2009-09-24 | — | — | WO | disclosed |