⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8880906 | 0.83 | — | — | |
| SCHEMBL30586002 | 0.81 | NAAA (0.32) | — | |
| SCHEMBL9175085 | 0.81 | ALDH1A1 (0.31) | — | |
| SCHEMBL10380732 | 0.76 | — | — | |
| SCHEMBL23174626 | 0.75 | — | — | |
| SCHEMBL4597101 | 0.75 | POLB (0.31) | — | |
| SCHEMBL20695063 | 0.73 | — | — | |
| SCHEMBL5838798 | 0.70 | — | — | |
| SCHEMBL1901109 | 0.70 | — | — | |
| Bicarbonate SCHEMBL9447127 | 0.68 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 37 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5214067-A | Mixture of pyranyl glycine ester and beta-lactone | MERCK & CO., INC. (US) | 1993-05-25 | — | — | US | claimed |
| US-9040706-B2 | Pyrrolidine inhibitors of IAP | GENENTECH, INC. (US) | 2015-05-26 | — | — | US | disclosed |
| US-8907092-B2 | Inhibitors of IAP | GENENTECH, INC. (US) | 2014-12-09 | — | — | US | disclosed |
| US-20140080805-A1 | PYRROLIDINE INHIBITORS OF IAP | GENENTECH, INC. (US) | 2014-03-20 | — | — | US | disclosed |
| US-8609845-B2 | Pyrrolidine inhibitors of IAP | GENENTECH, INC. (US) | 2013-12-17 | — | — | US | disclosed |
| EP-1836201-B2 | PYRROLIDINE INHIBITORS OF IAP | GENENTECH INC (US) | 2013-09-04 | — | — | EP | disclosed |
| EP-2240506-B1 | INHIBITORS OF IAP | GENENTECH INC (US) | 2012-12-26 | — | — | EP | disclosed |
| US-20120270886-A1 | INHIBITORS OF IAP | KOEHLER MICHAEL F T (US) | 2012-10-25 | — | — | US | disclosed |
| US-8247557-B2 | IAP inhibitors | GENENTECH, INC. (US) | 2012-08-21 | — | — | US | disclosed |
| US-20120015974-A1 | IMIDAZOPYRIDINE INHIBITORS OF IAP | GENENTECH, INC. (US) | 2012-01-19 | — | — | US | disclosed |
| US-20090176822-A1 | PYRROLIDINE INHIBITORS OF IAP | GENENTECH, INC. (US) | 2009-07-09 | — | — | US | disclosed |
| WO-2008134679-A1 | INHIBITORS OF IAP | GENENTECH, INC. (US) | 2008-11-06 | — | — | WO | disclosed |
| EP-1973899-A2 | INHIBITORS OF IAP | Genentech, Inc. (US) | 2008-10-01 | — | — | EP | disclosed |
| WO-2008079735-A1 | IMIDAZOPYRIDINE INHIBITORS OF IAP | GENENTECH, INC. (US) | 2008-07-03 | — | — | WO | disclosed |
| EP-1836201-A1 | PYRROLIDINE INHIBITORS OF IAP | Genentech, Inc. (US) | 2007-09-26 | — | — | EP | disclosed |
| WO-2007106192-A2 | INHIBITORS OF IAP | GENENTECH, INC. (US) | 2007-09-20 | — | — | WO | disclosed |
| US-20060167066-A1 | Pyrrolidine inhibitors of IAP | GENENTECH, INC. (US) | 2006-07-27 | — | — | US | disclosed |
| WO-2006069063-A1 | PYRROLIDINE INHIBITORS OF IAP | GENENTECH, INC. (US) | 2006-06-29 | — | — | WO | disclosed |
| US-5214067-A | Mixture of pyranyl glycine ester and beta-lactone | MERCK & CO., INC. (US) | 1993-05-25 | — | — | US | disclosed |
| EP-0479356-A1 | Fungicidal compositions and method | MERCK & CO. INC. (US) | 1992-04-08 | — | — | EP | disclosed |