Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 1/20 | 0.43 |
| ▸ | GALR2 | O43603 | 4/20 | 0.41 |
| ▸ | GALR1 | P47211 | 2/20 | 0.40 |
| ▸ | ABL1 | P00519 | 7/20 | 0.39 |
| ▸ | BCR | P11274 | 6/20 | 0.39 |
| ▸ | DHFR | P00374 | 1/20 | 0.39 |
| ▸ | BRAF | P15056 | 1/20 | 0.38 |
| ▸ | IDH1 | O75874 | 1/20 | 0.38 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.38 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.38 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.38 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3408722 | 0.93 | IGF1R (0.52) | IGF1RGALR2GALR1BRAFABCB1 | |
| SCHEMBL3404287 | 0.90 | GALR2 (0.41) | IGF1RGALR2GALR1ABL1BCR | |
| SCHEMBL3404327 | 0.88 | DHODH (0.43) | GALR2BRAFABCB1ABCC1ABCG2 | |
| SCHEMBL3410817 | 0.88 | GALR2 (0.39) | IGF1RGALR2GALR1ABL1BCR | |
| SCHEMBL3406352 | 0.87 | BRAF (0.46) | BRAFABCB1ABCC1ABCG2 | |
| SCHEMBL3410452 | 0.87 | BRAF (0.44) | GALR2GALR1BRAFABCB1ABCC1 | |
| SCHEMBL3410067 | 0.86 | IGF1R (0.47) | IGF1RGALR2GALR1BRAFABCB1 | |
| SCHEMBL3413181 | 0.85 | TP53 (0.48) | ABCB1ABCC1ABCG2 | |
| SCHEMBL3406368 | 0.85 | BRAF (0.52) | ABL1BRAFABCB1ABCC1ABCG2 | |
| SCHEMBL3412595 | 0.82 | MAPT (0.41) | BRAFABCB1ABCC1ABCG2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2257541-A1 | MODULATORS FOR AMYLOID BETA | F. Hoffmann-La Roche AG (CH) | 2010-12-08 | — | — | EP | disclosed |
| WO-2009103652-A1 | MODULATORS FOR AMYLOID BETA | F. HOFFMANN-LA ROCHE AG (CH) | 2009-08-27 | — | — | WO | disclosed |