Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 3/20 | 0.52 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.43 |
| ▸ | ABCG2 | Q9UNQ0 | 4/20 | 0.41 |
| ▸ | ABCC1 | P33527 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | STK10 | O94804 | 1/20 | 0.40 |
| ▸ | SLK | Q9H2G2 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3406352 | 0.94 | BRAF (0.46) | BRAFPDE4BABCG2ABCC1MAPT | |
| SCHEMBL3410452 | 0.91 | BRAF (0.44) | BRAFABCG2ABCC1MAPTTP53 | |
| SCHEMBL3413181 | 0.88 | TP53 (0.48) | ABCG2ABCC1MAPTTP53LMNA | |
| SCHEMBL3412595 | 0.87 | MAPT (0.41) | BRAFPDE4BABCG2ABCC1MAPT | |
| SCHEMBL3404327 | 0.86 | DHODH (0.43) | BRAFABCG2ABCC1MAPTTP53 | |
| SCHEMBL3408722 | 0.86 | IGF1R (0.52) | BRAFABCG2ABCC1MAPTMEN1 | |
| SCHEMBL3407803 | 0.85 | IGF1R (0.43) | BRAFABCG2ABCC1ABL1ABCB1 | |
| SCHEMBL3409746 | 0.83 | TP53 (0.47) | ABCG2ABCC1MAPTTP53LMNA | |
| SCHEMBL3413442 | 0.82 | GRM5 (0.41) | ABCG2ABCC1KDRABCB1 | |
| SCHEMBL3407298 | 0.80 | ABCB1 (0.39) | ABCG2ABCC1KDRABCB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2257541-A1 | MODULATORS FOR AMYLOID BETA | F. Hoffmann-La Roche AG (CH) | 2010-12-08 | — | — | EP | disclosed |
| WO-2009103652-A1 | MODULATORS FOR AMYLOID BETA | F. HOFFMANN-LA ROCHE AG (CH) | 2009-08-27 | — | — | WO | disclosed |