Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 2/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.46 |
| ▸ | USP2 | O75604 | 2/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.42 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.41 |
| ▸ | PSEN1 | P49768 | 4/20 | 0.39 |
| ▸ | PSEN2 | P49810 | 4/20 | 0.39 |
| ▸ | APH1B | Q8WW43 | 4/20 | 0.39 |
| ▸ | NCSTN | Q92542 | 4/20 | 0.39 |
| ▸ | APH1A | Q96BI3 | 4/20 | 0.39 |
| ▸ | PSENEN | Q9NZ42 | 4/20 | 0.39 |
| ▸ | ABCB1 | P08183 | 3/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3406368 | 0.94 | BRAF (0.52) | BRAFCYP1A2CYP2D6CYP2C19USP2 | |
| SCHEMBL3410452 | 0.91 | BRAF (0.44) | BRAFCYP1A2CYP2D6CYP2C19USP2 | |
| SCHEMBL3404327 | 0.89 | DHODH (0.43) | BRAFLMNAPSEN1PSEN2APH1B | |
| SCHEMBL3407803 | 0.87 | IGF1R (0.43) | BRAFABCB1ABCC1ABCG2 | |
| SCHEMBL3412595 | 0.87 | MAPT (0.41) | BRAFLMNAPDE4BABCB1ABCC1 | |
| SCHEMBL3408722 | 0.86 | IGF1R (0.52) | BRAFPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL3413181 | 0.85 | TP53 (0.48) | LMNAPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL3413442 | 0.82 | GRM5 (0.41) | ABCB1ABCC1ABCG2CDK9CCNT1 | |
| SCHEMBL3404331 | 0.81 | ABCB1 (0.41) | BRAFPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL3409746 | 0.81 | TP53 (0.47) | LMNAPSEN1PSEN2APH1BNCSTN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2257541-A1 | MODULATORS FOR AMYLOID BETA | F. Hoffmann-La Roche AG (CH) | 2010-12-08 | — | — | EP | disclosed |
| WO-2009103652-A1 | MODULATORS FOR AMYLOID BETA | F. HOFFMANN-LA ROCHE AG (CH) | 2009-08-27 | — | — | WO | disclosed |