Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 1/20 | 0.51 |
| ▸ | EEF2K | O00418 | 1/20 | 0.42 |
| ▸ | PLAU | P00749 | 2/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | JAK3 | P52333 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 6/20 | 0.37 |
| ▸ | RAB9A | P51151 | 6/20 | 0.37 |
| ▸ | NPC1 | O15118 | 5/20 | 0.37 |
| ▸ | SYK | P43405 | 1/20 | 0.36 |
| ▸ | F2RL3 | Q96RI0 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | CASP3 | P42574 | 1/20 | 0.36 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.36 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.36 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3411850 | 0.90 | IKBKB (0.48) | IKBKBEEF2KPLAUKCNH2SCN5A | |
| SCHEMBL3406686 | 0.88 | IKBKB (0.47) | IKBKBEEF2KPLAUKCNH2SCN5A | |
| SCHEMBL1176552 | 0.84 | IKBKB (0.70) | IKBKBEEF2KPLAUKCNH2SCN5A | |
| SCHEMBL3414143 | 0.83 | EEF2K (0.42) | IKBKBEEF2KMAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL3414021 | 0.83 | IKBKB (0.42) | IKBKBEEF2KPLAUKCNH2SCN5A | |
| SCHEMBL3414237 | 0.81 | IKBKB (0.41) | IKBKBEEF2KPLAUKCNH2SCN5A | |
| SCHEMBL3412095 | 0.81 | IKBKB (0.47) | IKBKBEEF2KPLAUMAPTRAB9A | |
| SCHEMBL3411616 | 0.80 | IKBKB (0.40) | IKBKBEEF2KPLAUKCNH2SCN5A | |
| SCHEMBL3657555 | 0.77 | EEF2K (0.46) | IKBKBEEF2KPLAUKCNH2SCN5A | |
| SCHEMBL3407940 | 0.74 | EEF2K (0.42) | IKBKBEEF2KMAPTSMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2260044-A2 | THIENOPYRIMIDINES | Merck Patent GmbH (DE) | 2010-12-15 | — | — | EP | disclosed |
| WO-2009124653-A2 | THIENOPYRIMIDINES | MERCK PATENT GMBH (DE) | 2009-10-15 | — | — | WO | disclosed |