Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EEF2K | O00418 | 1/20 | 0.42 |
| ▸ | BRAF | P15056 | 1/20 | 0.36 |
| ▸ | PDE4A | P27815 | 1/20 | 0.36 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.36 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.36 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.36 |
| ▸ | IKBKB | O14920 | 8/20 | 0.35 |
| ▸ | LIMK1 | P53667 | 2/20 | 0.35 |
| ▸ | CHUK | O15111 | 1/20 | 0.35 |
| ▸ | PRKACA | P17612 | 1/20 | 0.35 |
| ▸ | PRKACG | P22612 | 1/20 | 0.35 |
| ▸ | PRKACB | P22694 | 1/20 | 0.35 |
| ▸ | BTK | Q06187 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 3/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3414143 | 0.91 | EEF2K (0.42) | EEF2KIKBKBLIMK1CHUKPRKACA | |
| SCHEMBL3410981 | 0.83 | LIMK1 (0.42) | BRAFPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL1176334 | 0.83 | EEF2K (0.60) | EEF2KBRAFPDE4APDE4BPDE4C | |
| SCHEMBL3411618 | 0.82 | EEF2K (0.39) | EEF2KKDM4EALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL3413366 | 0.82 | IKBKB (0.41) | EEF2KIKBKBLIMK1KDM4EALDH1A1 | |
| SCHEMBL3411850 | 0.81 | IKBKB (0.48) | EEF2KBRAFPDE4APDE4BPDE4C | |
| SCHEMBL3407525 | 0.77 | LIMK1 (0.45) | EEF2KIKBKBLIMK1KDM4EALDH1A1 | |
| SCHEMBL3655704 | 0.77 | BRAF (0.45) | EEF2KBRAFKDM4EALDH1A1HPGD | |
| SCHEMBL3407889 | 0.74 | IKBKB (0.51) | EEF2KIKBKBKDM4EALDH1A1HPGD | |
| SCHEMBL3414045 | 0.74 | TGFBR1 (0.37) | BRAFPDE4APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2260044-A2 | THIENOPYRIMIDINES | Merck Patent GmbH (DE) | 2010-12-15 | — | — | EP | claimed |
| WO-2009124653-A2 | THIENOPYRIMIDINES | MERCK PATENT GMBH (DE) | 2009-10-15 | — | — | WO | claimed |
| EP-2260044-A2 | THIENOPYRIMIDINES | Merck Patent GmbH (DE) | 2010-12-15 | — | — | EP | disclosed |
| WO-2009124653-A2 | THIENOPYRIMIDINES | MERCK PATENT GMBH (DE) | 2009-10-15 | — | — | WO | disclosed |