Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Moclobemide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA known ✓ | P21397 | 1/20 | 1.00 |
| ▸ | CD274 | Q9NZQ7 | 5/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 1.00 |
| ▸ | HTR1A | P08908 | 1/20 | 1.00 |
| ▸ | MAOB | P27338 | 1/20 | 1.00 |
| ▸ | KCNH2 | Q12809 | 1/20 | 1.00 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.83 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.72 |
| ▸ | HPGD | P15428 | 1/20 | 0.71 |
| ▸ | CNR1 | P21554 | 1/20 | 0.67 |
| ▸ | POLB | P06746 | 1/20 | 0.66 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Moclobemide SCHEMBL49708 | 1.00 | CD274 (1.00) | CD274ALDH1A1HTR1AMAOAMAOB | |
| Moclobemide SCHEMBL11475483 | 0.99 | CD274 (0.97) | CD274ALDH1A1HTR1AMAOAMAOB | |
| Eprobemide SCHEMBL570896 | 0.92 | ALDH1A1 (0.85) | CD274ALDH1A1HTR1AMAOAMAOB | |
| Eprobemide SCHEMBL10495496 | 0.91 | ALDH1A1 (0.82) | CD274ALDH1A1HTR1AMAOAMAOB | |
| SCHEMBL10723708 | 0.90 | ALDH1A1 (0.85) | CD274ALDH1A1HTR1AMAOAMAOB | |
| SCHEMBL4488493 | 0.87 | CD274 (0.77) | CD274ALDH1A1HTR1AMAOAMAOB | |
| SCHEMBL6569882 | 0.87 | CD274 (0.77) | CD274ALDH1A1HTR1AMAOAMAOB | |
| SCHEMBL2251460 | 0.86 | CD274 (0.76) | CD274ALDH1A1HTR1AMAOAMAOB | |
| SCHEMBL6034019 | 0.86 | TSHR (0.85) | CD274ALDH1A1HTR1AMAOAMAOB | |
| SCHEMBL2615239 | 0.86 | CD274 (0.92) | CD274ALDH1A1HTR1AMAOAMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012151309-A1 | METHODS FOR REGULATING INDUCED PLURIPOTENT STEM CELL GENERATION AND COMPOSITIONS THEREOF | SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE (US) | 2012-11-08 | — | — | WO | disclosed |
| EP-2254564-A1 | COMBINATIONS COMPRISING 3-PHENYLSULFONYL-8-PIPERAZINYL-1YL-QUINOLINE | Glaxo Group Limited (GB) | 2010-12-01 | — | — | EP | disclosed |
| WO-2009074607-A1 | COMBINATIONS COMPRISING 3-PHENYLSULFONYL-8-PIPERAZINYL-1YL-QUINOLINE | GLAXO GROUP LIMITED (GB) | 2009-06-18 | — | — | WO | disclosed |
| WO-2000006138-A2 | USE OF MOCLOBEMIDE FOR TREATING PAIN AND OTHER DISEASES | VELA PHARMACEUTICALS INC. (US) | 2000-02-10 | — | — | WO | disclosed |