Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGDS | O60760 | 3/20 | 0.55 |
| ▸ | P4HTM | Q9NXG6 | 2/20 | 0.51 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | GRM5 | P41594 | 1/20 | 0.49 |
| ▸ | F7 | P08709 | 1/20 | 0.48 |
| ▸ | F3 | P13726 | 1/20 | 0.48 |
| ▸ | SARM1 | Q6SZW1 | 1/20 | 0.48 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.48 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.48 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.48 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.48 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.48 |
| ▸ | SIRT4 | Q9Y6E7 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.48 |
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | BLM | P54132 | 2/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL945366 | 0.84 | P4HTM (0.68) | HPGDSP4HTMCHEK2KDM4ETDP1 | |
| SCHEMBL1671397 | 0.83 | KDM4E (0.61) | HPGDSP4HTMKDM4ETDP1TP53 | |
| Dipyridyl SCHEMBL15380517 | 0.82 | TDP1 (0.67) | P4HTMCHEK2KDM4ETDP1TP53 | |
| Hydrochloric Acid SCHEMBL28173955 | 0.82 | P4HTM (0.66) | HPGDSP4HTMCHEK2KDM4ETDP1 | |
| SCHEMBL11891928 | 0.81 | HPGDS (0.55) | HPGDSP4HTMKDM4ETDP1TP53 | |
| Hydrochloric Acid SCHEMBL3216270 | 0.81 | HPGDS (0.59) | HPGDSP4HTMKDM4ETDP1TP53 | |
| SCHEMBL3220170 | 0.81 | HPGDS (0.55) | HPGDSP4HTMKDM4ETDP1TP53 | |
| Hydrochloric Acid SCHEMBL11027155 | 0.80 | HPGDS (0.54) | HPGDSP4HTMKDM4ETDP1TP53 | |
| SCHEMBL3407187 | 0.80 | NNMT (0.48) | HPGDSKDM4ETDP1GRM5F7 | |
| Dipyridyl SCHEMBL28724644 | 0.79 | KDM4E (0.56) | P4HTMCHEK2KDM4ETDP1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116997548-A | HTT modulators for the treatment of huntington's disease | CHDI基金会股份有限公司 | 2023-11-03 | — | — | CN | disclosed |
| EP-2257539-A1 | SUBSTITUTED 4-HYDROXYPYRIMIDINE-5-CARBOXAMIDES | Merck Sharp & Dohme Corp. (US) | 2010-12-08 | — | — | EP | disclosed |
| WO-2009117269-A1 | SUBSTITUTED 4-HYDROXYPYRIMIDINE-5-CARBOXAMIDES | MERCK & CO., INC. (US) | 2009-09-24 | — | — | WO | disclosed |