Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 11/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.31 |
| ▸ | SNCA | P37840 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2290893 | 0.83 | NAMPT (0.53) | NAMPTLMNASNCA | |
| SCHEMBL3407377 | 0.80 | FAAH (0.43) | NAMPTMAPTHTT | |
| SCHEMBL3406868 | 0.79 | NAMPT (0.38) | NAMPTLMNAHTT | |
| SCHEMBL3406866 | 0.77 | SCD (0.52) | NAMPT | |
| SCHEMBL3408430 | 0.75 | HPGD (0.49) | NAMPTLMNAMAPT | |
| SCHEMBL2299341 | 0.69 | NAMPT (0.54) | NAMPTLMNASNCA | |
| SCHEMBL2297207 | 0.67 | OGA (0.48) | LMNAMAPTHRH3HTT | |
| SCHEMBL8098134 | 0.67 | NAMPT (0.49) | NAMPTLMNASNCA | |
| SCHEMBL3407350 | 0.66 | NAMPT (0.46) | NAMPTLMNASNCA | |
| SCHEMBL4035553 | 0.65 | HDAC2 (0.40) | LMNAMAPTHRH3SNCA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2152711-B1 | 2 -HETEROARYL- PYRROLO [3, 4-C]PYRROLE DERIVATIVES AND THEIR USE AS SCD INHIBITORS | SANOFI AVENTIS (FR) | 2010-11-24 | — | — | EP | disclosed |
| EP-2152711-A1 | 2 -HETEROARYL- PYRROLO [3, 4-C]PYRROLE DERIVATIVES AND THEIR USE AS SCD INHIBITORS | Sanofi-Aventis (FR) | 2010-02-17 | — | — | EP | disclosed |
| WO-2008135141-A1 | 2 -HETEROARYL- PYRROLO [3, 4-C] PYRROLE DERIVATIVES AND THEIR USE AS SCD INHIBITORS | SANOFI-AVENTIS (FR) | 2008-11-13 | — | — | WO | disclosed |