Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCA | P17252 | 7/20 | 0.62 |
| ▸ | PRKCD | Q05655 | 3/20 | 0.62 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.62 |
| ▸ | PRKCG | P05129 | 1/20 | 0.62 |
| ▸ | PRKCB | P05771 | 1/20 | 0.62 |
| ▸ | LCK | P06239 | 1/20 | 0.62 |
| ▸ | PRKCH | P24723 | 1/20 | 0.62 |
| ▸ | PRKCI | P41743 | 1/20 | 0.62 |
| ▸ | ZAP70 | P43403 | 1/20 | 0.62 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.62 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.62 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.62 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.62 |
| ▸ | ABL1 | P00519 | 15/20 | 0.54 |
| ▸ | BCR | P11274 | 14/20 | 0.54 |
| ▸ | PDGFRB | P09619 | 4/20 | 0.52 |
| ▸ | PDGFRA | P16234 | 4/20 | 0.52 |
| ▸ | EGFR | P00533 | 3/20 | 0.52 |
| ▸ | SRC | P12931 | 2/20 | 0.52 |
| ▸ | PRKACA | P17612 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3407305 | 0.86 | PIK3CA (0.61) | PRKCAZAP70EGFRRET | |
| SCHEMBL3409757 | 0.85 | CDK9 (0.47) | PRKCAPRKCDPRKD3PRKCGPRKCB | |
| SCHEMBL3409641 | 0.84 | PIK3CA (0.49) | PRKCAPRKCDPRKD3PRKCGPRKCB | |
| SCHEMBL3413279 | 0.83 | CDK2 (0.46) | PRKCAPRKCDPRKD3PRKCGPRKCB | |
| SCHEMBL3409953 | 0.83 | PIK3CA (0.49) | LCKABL1PDGFRBEGFRACVR1 | |
| SCHEMBL3412789 | 0.81 | SYK (0.56) | ZAP70SRCRET | |
| SCHEMBL3407822 | 0.81 | PIK3CA (0.59) | EGFRRET | |
| SCHEMBL3409753 | 0.81 | PIK3CA (0.52) | EGFRRET | |
| SCHEMBL3412646 | 0.80 | SYK (0.46) | RET | |
| SCHEMBL3408737 | 0.80 | RET (0.41) | LCKZAP70EGFRSRCRET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2257541-A1 | MODULATORS FOR AMYLOID BETA | F. Hoffmann-La Roche AG (CH) | 2010-12-08 | — | — | EP | disclosed |
| WO-2009103652-A1 | MODULATORS FOR AMYLOID BETA | F. HOFFMANN-LA ROCHE AG (CH) | 2009-08-27 | — | — | WO | disclosed |