Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 7/20 | 0.49 |
| ▸ | PIK3CG | P48736 | 7/20 | 0.49 |
| ▸ | PIK3CB | P42338 | 6/20 | 0.49 |
| ▸ | EGFR | P00533 | 3/20 | 0.49 |
| ▸ | JAK2 | O60674 | 3/20 | 0.49 |
| ▸ | CDK2 | P24941 | 2/20 | 0.49 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.49 |
| ▸ | RET | P07949 | 1/20 | 0.43 |
| ▸ | ZAP70 | P43403 | 5/20 | 0.42 |
| ▸ | CDK9 | P50750 | 3/20 | 0.42 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.42 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.42 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.42 |
| ▸ | PRKD3 | O94806 | 3/20 | 0.42 |
| ▸ | PRKCG | P05129 | 3/20 | 0.42 |
| ▸ | PRKCB | P05771 | 3/20 | 0.42 |
| ▸ | LCK | P06239 | 3/20 | 0.42 |
| ▸ | PRKCA | P17252 | 3/20 | 0.42 |
| ▸ | PRKCH | P24723 | 3/20 | 0.42 |
| ▸ | PRKCI | P41743 | 3/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3407305 | 0.91 | PIK3CA (0.61) | PIK3CAPIK3CGPIK3CBEGFRJAK2 | |
| SCHEMBL3409753 | 0.88 | PIK3CA (0.52) | PIK3CAPIK3CGPIK3CBEGFRJAK2 | |
| SCHEMBL3407822 | 0.86 | PIK3CA (0.59) | PIK3CAPIK3CGPIK3CBEGFRJAK2 | |
| SCHEMBL3409953 | 0.86 | PIK3CA (0.49) | PIK3CAPIK3CGPIK3CBEGFRJAK2 | |
| SCHEMBL3413279 | 0.84 | CDK2 (0.46) | PIK3CAPIK3CGPIK3CBEGFRJAK2 | |
| SCHEMBL3408743 | 0.84 | PRKCA (0.62) | EGFRRETZAP70PRKD3PRKCG | |
| SCHEMBL3409757 | 0.84 | CDK9 (0.47) | PIK3CAPIK3CGPIK3CBEGFRJAK2 | |
| SCHEMBL3412789 | 0.80 | SYK (0.56) | CDK2RETZAP70CDK9CCNT1 | |
| SCHEMBL3406073 | 0.80 | PIK3CA (0.41) | PIK3CAPIK3CGPIK3CBEGFRPRKCQ | |
| SCHEMBL3412646 | 0.79 | SYK (0.46) | CDK2RETCDK9CCNT1DYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2257541-A1 | MODULATORS FOR AMYLOID BETA | F. Hoffmann-La Roche AG (CH) | 2010-12-08 | — | — | EP | disclosed |
| WO-2009103652-A1 | MODULATORS FOR AMYLOID BETA | F. HOFFMANN-LA ROCHE AG (CH) | 2009-08-27 | — | — | WO | disclosed |