SCHEMBL3408787

SCHEMBL3408787

O=c1ccc2ccc(OCc3ccc(F)cc3)cc2o1

nearest known ligand 0.75

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAOB P27338 6/20 0.75
NPC1 O15118 3/20 0.75
MAOA P21397 2/20 0.75
RAB9A P51151 2/20 0.75
CA12 O43570 5/20 0.74
CA1 P00915 5/20 0.74
CA9 Q16790 4/20 0.74
CA4 P22748 3/20 0.74
CA7 P43166 3/20 0.74
CA2 P00918 2/20 0.74
CA6 P23280 2/20 0.74
CA14 Q9ULX7 2/20 0.74
MEN1 O00255 1/20 0.74
CA3 P07451 1/20 0.74
MTNR1A P48039 1/20 0.74
KMT2A Q03164 1/20 0.74
CA5A P35218 2/20 0.68
CA5B Q9Y2D0 2/20 0.68
ACHE P22303 2/20 0.64
SLC16A3 O15427 1/20 0.64

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29858559 1.00 MAOB (0.75) MAOBNPC1MAOARAB9ACA12
SCHEMBL21647395 0.87 MAOB (0.77) MAOBNPC1MAOARAB9ACA12
SCHEMBL28440199 0.86 MAOB (1.00) MAOBNPC1MAOARAB9ACA12
SCHEMBL29724665 0.86 MAOB (1.00) MAOBNPC1MAOARAB9ACA12
SCHEMBL16516672 0.86 MAOB (0.75) MAOBNPC1MAOARAB9ACA12
7-Benzyloxycoumarin SCHEMBL3901170 0.85 MAOB (1.00) MAOBNPC1MAOARAB9ACA12
7-Benzyloxycoumarin SCHEMBL29365449 0.85 MAOB (1.00) MAOBNPC1MAOARAB9ACA12
SCHEMBL16001395 0.83 NPC1 (0.70) MAOBNPC1MAOARAB9ACA12
SCHEMBL16004381 0.82 MAOB (0.70) MAOBNPC1MAOARAB9ACA12
SCHEMBL5617763 0.82 NPC1 (0.74) MAOBNPC1MAOARAB9ACA12

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 73 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20170189477-A1 Methods and Compositions of P27KIP1 Transcriptional Modulators NIH-DEITR 2017-07-06 US claimed
US-9572815-B2 Methods and compositions of p27KIP1 transcriptional modulators ST. JUDE CHILDREN'S RESEARCH HOSPITAL (US) 2017-02-21 US claimed
US-20160030445-A1 METHODS AND COMPOSITIONS OF P27KIP1 TRANSCRIPTIONAL MODULATORS ST. JUDE CHILDREN'S RESEARCH HOSPITAL (US) 2016-02-04 US claimed
WO-2014145205-A2 METHODS AND COMPOSITIONS OF P27KIP1 TRANSCRIPTION MODULATORS ST. JUDE CHILDREN'S RESEARCH HOSPITAL (US) 2014-09-18 WO claimed
EP-2254572-A2 COMPOUNDS THAT ENHANCE ATOH-1 EXPRESSION Massachusetts Eye & Ear Infirmary (US) 2010-12-01 EP claimed
US-20090232780-A1 COMPOUNDS THAT ENHANCE ATOH1 EXPRESSION MASSACHUSETTS EYE & EAR INFIRMARY (US) 2009-09-17 US claimed
WO-2009100438-A2 COMPOUNDS THAT ENHANCE ATOH-1 EXPRESSION MASSACHUSETTS EYE & EAR INFIRMARY (US) 2009-08-13 WO claimed
US-20250099539-A1 METHODS AND COMPOSITIONS FOR REGENERATING HAIR CELLS AND/OR SUPPORTING CELLS MASSACHUSETTS EYE AND EAR INFIRMARY 2025-03-27 US disclosed
US-12239651-B2 Treatment of hearing loss MASSACHUSETTS EYE AND EAR INFIRMARY (US) 2025-03-04 US disclosed
US-12156899-B2 Methods and compositions for regenerating hair cells and/or supporting cells MASSACHUSETTS EYE AND EAR INFIRMARY (US) 2024-12-03 US disclosed
US-20240299432-A1 TREATMENT OF HEARING LOSS MASSACHUSETTS EYE AND EAR INFIRMARY 2024-09-12 US disclosed
US-12043653-B2 Efficient delivery of therapeutic molecules to cells of the inner ear MASSACHUSETTS EYE AND EAR INFIRMARY (US) 2024-07-23 US disclosed
US-11963968-B2 Treatment of hearing loss MASSACHUSETTS EYE AND EAR INFIRMARY (US) 2024-04-23 US disclosed
US-8188131-B2 Compounds that enhance Atoh1 expression MASSACHUSETTS EYE & EAR INFIRMARY (US) 2012-05-29 US disclosed
US-8188131-B2 Compounds that enhance Atoh1 expression MASSACHUSETTS EYE & EAR INFIRMARY (US) 2012-05-29 US disclosed
US-8188131-B2 Compounds that enhance Atoh1 expression MASSACHUSETTS EYE & EAR INFIRMARY (US) 2012-05-29 US disclosed
US-20090232780-A1 COMPOUNDS THAT ENHANCE ATOH1 EXPRESSION MASSACHUSETTS EYE & EAR INFIRMARY (US) 2009-09-17 US disclosed
US-20090232780-A1 COMPOUNDS THAT ENHANCE ATOH1 EXPRESSION MASSACHUSETTS EYE & EAR INFIRMARY (US) 2009-09-17 US disclosed
US-20090232780-A1 COMPOUNDS THAT ENHANCE ATOH1 EXPRESSION MASSACHUSETTS EYE & EAR INFIRMARY (US) 2009-09-17 US disclosed
WO-2009100438-A2 COMPOUNDS THAT ENHANCE ATOH-1 EXPRESSION MASSACHUSETTS EYE & EAR INFIRMARY (US) 2009-08-13 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240299432-A1 TREATMENT OF HEARING LOSS HES1, NOTCH1, NOTCH4 MAOB 4705/4885NPC1 1607/4885MAOA 4780/4885
US-12043653-B2 Efficient delivery of therapeutic molecules to cells of the inner ear HES1, NOTCH1, NOTCH2 MAOB 4725/4885NPC1 1630/4885MAOA 4710/4885
US-20170189477-A1 Methods and Compositions of P27KIP1 Transcriptional Modulators WNT1, CTNNB1, CTNNBL1 MAOB 4744/4885NPC1 1011/4885MAOA 4675/4885
US-12156899-B2 Methods and compositions for regenerating hair cells and/or supporting cells HES1, NOTCH1, NOTCH4 MAOB 4013/4885NPC1 1656/4885MAOA 4210/4885
US-20250099539-A1 METHODS AND COMPOSITIONS FOR REGENERATING HAIR CELLS AND/OR SUPPORTING CELLS HES1, NOTCH1, NOTCH4 MAOB 4013/4885NPC1 1656/4885MAOA 4210/4885
US-20160030445-A1 METHODS AND COMPOSITIONS OF P27KIP1 TRANSCRIPTIONAL MODULATORS WNT1, CTNNB1, CTNNBL1 MAOB 4723/4885NPC1 966/4885MAOA 4685/4885
US-20090232780-A1 COMPOUNDS THAT ENHANCE ATOH1 EXPRESSION DACH1, EZH1, CREBBP MAOB 2727/4885NPC1 1018/4885MAOA 2593/4885
US-12239651-B2 Treatment of hearing loss HES1, NOTCH1, NOTCH4 MAOB 4705/4885NPC1 1607/4885MAOA 4780/4885
US-11963968-B2 Treatment of hearing loss HES1, NOTCH1, NOTCH4 MAOB 4705/4885NPC1 1607/4885MAOA 4780/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.