Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.33 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.33 |
| ▸ | PPARG | P37231 | 3/20 | 0.33 |
| ▸ | OXER1 | Q8TDS5 | 3/20 | 0.33 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | RXRA | P19793 | 2/20 | 0.33 |
| ▸ | SNCA | P37840 | 2/20 | 0.33 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | FAAH | O00519 | 1/20 | 0.33 |
| ▸ | CNR1 | P21554 | 1/20 | 0.33 |
| ▸ | CNR2 | P34972 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 3/20 | 0.32 |
| ▸ | F7 | P08709 | 3/20 | 0.32 |
| ▸ | F3 | P13726 | 3/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL16004643 | 0.96 | HIF1A (0.44) | HIF1AEPHX2ALDH1A1SNCACYP1A2 | |
| Bromide SCHEMBL11584557 | 0.96 | HIF1A (0.44) | HIF1AEPHX2ALDH1A1SNCACYP1A2 | |
| Bromide SCHEMBL8925807 | 0.85 | HIF1A (0.55) | HIF1AALDH1A1SNCACYP1A2CYP2D6 | |
| Bromide SCHEMBL10861426 | 0.81 | HIF1A (0.48) | HIF1AEPHX2ALDH1A1CYP19A1PPARG | |
| Bromide SCHEMBL10861418 | 0.81 | HIF1A (0.48) | HIF1AEPHX2ALDH1A1CYP19A1PPARG | |
| Hydrochloric Acid SCHEMBL2447465 | 0.81 | HIF1A (0.55) | HIF1AALDH1A1SNCACYP1A2CYP2D6 | |
| Hydrochloric Acid SCHEMBL14839973 | 0.81 | HIF1A (0.55) | HIF1AALDH1A1SNCACYP1A2CYP2D6 | |
| Bromide SCHEMBL9594082 | 0.81 | HIF1A (0.46) | HIF1AALDH1A1SNCACYP1A2CYP2D6 | |
| Bromide SCHEMBL9594079 | 0.81 | HIF1A (0.46) | HIF1AALDH1A1SNCACYP1A2CYP2D6 | |
| SCHEMBL29770027 | 0.79 | HIF1A (0.50) | HIF1AEPHX2ALDH1A1CYP19A1PPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7749551-B2 | Mint composition | TAKASAGO INTERNATIONAL CORPORATION (JP) | 2010-07-06 | — | — | US | disclosed |
| US-20070218178-A1 | MINT COMPOSITION | TAKASAGO INTERNATIONAL CORPORATION (JP) | 2007-09-20 | — | — | US | disclosed |