Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 1/20 | 0.44 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | RAB9A | P51151 | 4/20 | 0.41 |
| ▸ | NPC1 | O15118 | 3/20 | 0.41 |
| ▸ | SLC2A1 | P11166 | 3/20 | 0.41 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.40 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | GAA | P10253 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | ALDH1A3 | P47895 | 1/20 | 0.39 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.38 |
| ▸ | TUBB | P07437 | 1/20 | 0.38 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.38 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.38 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.38 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL218181 | 0.77 | MAPT (0.47) | CYP11B1CYP11B2MAPTRAB9ANPC1 | |
| SCHEMBL679068 | 0.77 | NPC1 (0.50) | MAPTRAB9ANPC1ATMALDH1A1 | |
| SCHEMBL22627444 | 0.70 | RAB9A (0.72) | MAPTRAB9ANPC1ATMALDH1A1 | |
| SCHEMBL6520038 | 0.69 | NR1H4 (0.47) | CYP11B1CYP11B2MAPTRAB9ANPC1 | |
| SCHEMBL220001 | 0.69 | HIF1A (0.57) | CYP11B1CYP11B2MAPTRAB9ANPC1 | |
| SCHEMBL17626204 | 0.69 | MAPT (0.42) | MAPTRAB9ANPC1ATMALDH1A1 | |
| SCHEMBL2749440 | 0.68 | CYP1B1 (0.50) | RAB9ANPC1ALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL3409155 | 0.68 | CYP11B1 (0.49) | CYP11B1CYP11B2MAPTRAB9ANPC1 | |
| SCHEMBL21566092 | 0.68 | CYP11B1 (0.47) | CYP11B1CYP11B2MAPTRAB9ANPC1 | |
| SCHEMBL6527443 | 0.67 | NR4A2 (0.47) | CYP11B1CYP11B2MAPTRAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2262804-A1 | POLYSUBSTITUTED DERIVATIVES OF 6-HETEROARYL-IMIDAZO[L,2- A] PYRIDINES, AND PREPARATION AND THERAPEUTIC USE THEREOF | Sanofi-aventis (FR) | 2010-12-22 | — | — | EP | disclosed |
| WO-2009144392-A1 | POLYSUBSTITUTED DERIVATIVES OF 6-HETEROARYL-IMIDAZO[L,2- Α] PYRIDINES, AND PREPARATION AND THERAPEUTIC USE THEREOF | SANOFI-AVENTIS (FR) | 2009-12-03 | — | — | WO | disclosed |