Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 3/20 | 0.32 |
| ▸ | RAB9A | P51151 | 3/20 | 0.32 |
| ▸ | GAA | P10253 | 2/20 | 0.32 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.32 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.31 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.31 |
| ▸ | RELA | Q04206 | 1/20 | 0.31 |
| ▸ | MITF | O75030 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.30 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1180023 | 0.75 | KDM4E (0.53) | MEN1TP53KMT2ANPC1GAA | |
| SCHEMBL3409326 | 0.75 | GRM5 (0.33) | GRM5PKMMEN1TP53KMT2A | |
| SCHEMBL1180025 | 0.73 | GRM5 (0.32) | GRM5PKMMEN1TP53KMT2A | |
| SCHEMBL16481895 | 0.71 | L3MBTL1 (0.47) | GRM5HSD17B10GAAL3MBTL1HCRTR1 | |
| SCHEMBL12622294 | 0.66 | NOS3 (0.50) | MEN1KMT2ANPC1RAB9AGAA | |
| SCHEMBL3084862 | 0.62 | NOS3 (0.55) | PKMMEN1KMT2ANPC1RAB9A | |
| SCHEMBL29648194 | 0.62 | NOS3 (0.55) | PKMMEN1KMT2ANPC1RAB9A | |
| SCHEMBL1179422 | 0.60 | GRM5 (0.39) | GRM5PKMMEN1TP53KMT2A | |
| SCHEMBL1179159 | 0.60 | S1PR1 (0.38) | HSD17B10NPC1RAB9AGAAS1PR1 | |
| SCHEMBL1179883 | 0.60 | KDM4E (0.43) | MEN1KMT2ANPC1RAB9AGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2262800-A1 | NOVEL PYRIMIDINE-PYRIDINE DERIVATIVES | Actelion Pharmaceuticals Ltd. (CH) | 2010-12-22 | — | — | EP | disclosed |
| WO-2009109907-A1 | NOVEL PYRIMIDINE-PYRIDINE DERIVATIVES | ACTELION PHARMACEUTICALS LTD (CH) | 2009-09-11 | — | — | WO | disclosed |