Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 4/20 | 0.36 |
| ▸ | EHMT2 | Q96KQ7 | 2/20 | 0.35 |
| ▸ | EHMT1 | Q9H9B1 | 1/20 | 0.35 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.34 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.34 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.34 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.34 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.34 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.34 |
| ▸ | IMPDH2 | P12268 | 6/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | PDE7A | Q13946 | 2/20 | 0.34 |
| ▸ | ULK1 | O75385 | 1/20 | 0.33 |
| ▸ | ULK2 | Q8IYT8 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.32 |
| ▸ | IMPDH1 | P20839 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3408862 | 0.87 | NPC1 (0.43) | EHMT2EHMT1IMPDH2NPC1RAB9A | |
| SCHEMBL3410560 | 0.86 | NPC1 (0.37) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL3410112 | 0.84 | PSEN1 (0.36) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL3411934 | 0.83 | CDK1 (0.35) | EHMT2EHMT1PSEN1PSEN2APH1B | |
| SCHEMBL3411116 | 0.83 | KCNH2 (0.49) | EHMT2EHMT1IMPDH2NPC1RAB9A | |
| SCHEMBL3408737 | 0.83 | RET (0.41) | ULK1ULK2 | |
| SCHEMBL3410528 | 0.83 | GALR2 (0.42) | — | |
| SCHEMBL3412580 | 0.82 | GALR2 (0.44) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL3409722 | 0.82 | PIK3CA (0.41) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL3409733 | 0.82 | CDK9 (0.41) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2257541-A1 | MODULATORS FOR AMYLOID BETA | F. Hoffmann-La Roche AG (CH) | 2010-12-08 | — | — | EP | disclosed |
| WO-2009103652-A1 | MODULATORS FOR AMYLOID BETA | F. HOFFMANN-LA ROCHE AG (CH) | 2009-08-27 | — | — | WO | disclosed |