Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.43 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.43 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.43 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.43 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.43 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.43 |
| ▸ | ABCG2 | Q9UNQ0 | 4/20 | 0.42 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.42 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.42 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.42 |
| ▸ | STK10 | O94804 | 1/20 | 0.42 |
| ▸ | SLK | Q9H2G2 | 1/20 | 0.42 |
| ▸ | APP | P05067 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | EGFR | P00533 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3413181 | 0.95 | TP53 (0.48) | TP53MAPTLMNATHRBMAPK1 | |
| SCHEMBL3404331 | 0.91 | ABCB1 (0.41) | TP53PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL3410953 | 0.90 | ABCB1 (0.44) | TP53MAPTPSEN1PSEN2APH1B | |
| SCHEMBL3410067 | 0.90 | IGF1R (0.47) | TP53MAPTPSEN1PSEN2APH1B | |
| SCHEMBL3404327 | 0.88 | DHODH (0.43) | TP53MAPTLMNATHRBMAPK1 | |
| SCHEMBL3412202 | 0.88 | MAPT (0.42) | TP53MAPTPSEN1PSEN2APH1B | |
| SCHEMBL3404287 | 0.87 | GALR2 (0.41) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL3406368 | 0.83 | BRAF (0.52) | TP53MAPTLMNAMAPK1ABCG2 | |
| SCHEMBL3410452 | 0.82 | BRAF (0.44) | TP53MAPTABCG2ABCB1ABCC1 | |
| SCHEMBL3408722 | 0.82 | IGF1R (0.52) | MAPTMAPK1PSEN1PSEN2APH1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2257541-A1 | MODULATORS FOR AMYLOID BETA | F. Hoffmann-La Roche AG (CH) | 2010-12-08 | — | — | EP | disclosed |
| WO-2009103652-A1 | MODULATORS FOR AMYLOID BETA | F. HOFFMANN-LA ROCHE AG (CH) | 2009-08-27 | — | — | WO | disclosed |